Searchable abstracts of presentations at key conferences in endocrinology

ea0086p362 | Reproductive Endocrinology | SFEBES2022

Clinical utility of GnRH analogues in female androgen excess: diagnostic and therapeutic implications

Madden Doyle Lauren , Cussen Leanne , McDonnell Tara , O'Reilly Michael W

Rare causes of severe androgen excess (AE) can present a diagnostic challenge to endocrinologists. Imaging may not identify occult ovarian pathology, and the detection of adrenal nodular disease may be indicative of incidental pathology. GnRH analogues can be used both as a medical treatment and as a diagnostic utility to confirm ovarian source, particularly in women with a preferential elevation of serum testosterone (T). In this case series, we present three cases highlighti...

ea0086p354 | Neuroendocrinology and Pituitary | SFEBES2022

Primary CNS lymphoma presenting with cranial diabetes insipidus – a case series

Madden Doyle Lauren , Cussen Leanne , McDonnell Tara , O'Reilly Michael W , Agha Amar

Primary CNS lymphoma (PCNSL) accounts for 0.85% - 2.0% of primary brain tumours. PCNSL arises in periventricular regions of the corpus callosum, with hypothalamic involvement less commonly. While cases have been reported in the literature, cranial diabetes insipidus (CDI) secondary to PCNSL is a rare phenomenon. We present this case series of three patients from our institution diagnosed with CDI and panhypopituitarism in the context of PCNSL.Cases: 1. 3...

ea0086p358 | Reproductive Endocrinology | SFEBES2022

The reproductive years: the experience of women attending routine diabetes care

McDonnell Tara , O'Connor Aisling , Cussen Leanne , Madden Doyle Lauren , Forde Hannah , Smith Diarmuid , O'Reilly Michael W.

Reproductive morbidity is increased in women with diabetes, including a higher prevalence of polycystic ovary syndrome, hypothalamic amenorrhoea and premature ovarian failure. Routine discussion of reproductive and menstrual dysfunction for women with diabetes remains a peripheral feature of clinical consultations. Here we aimed to determine womenÂ’s own reproductive care experience. We surveyed women of all ages attending routine diabetes care using a detailed clinical qu...

ea0091wg3 | Workshop G: Disorders of appetite and weight | SFEEU2023

Clinical utility of GnRH analogues in female androgen excess due to severe insulin resistance

Cussen Leanne , McDonnell Tara , Miller Clare , Madden Doyle Lauren , W O'Reilly Michael

Lipodystrophy represents a broad spectrum of disorders, subdivided depending on aetiology (congenital or acquired) or the extent of adipose tissue absence (generalised or partial). A lack of adipose tissue results in systemic insulin resistance and ectopic fat deposition, which predisposes patients to metabolic syndrome and associated conditions such as non-alcoholic fatty liver disease and diabetes mellitus. Additionally, severe hyperinsulinaemia can generate ovarian androgen...

ea0094p12 | Adrenal and Cardiovascular | SFEBES2023

Service evaluation suggests variation in clinical care provision in adults with congenital adrenal hyperplasia in the UK and Ireland

Madden Doyle Lauren , Faisal Ahmed Syed , Elford Sue , Elhassan Yasir , James Lynette , Lawrence Neil , Llahana Sofia , Rees Aled , Tomlinson Jeremy , O'Reilly Michael , Krone Nils

Background: The Congenital adrenal Hyperplasia (CAH) Adult Study Executive (CaHASE) identified poor metabolic outcomes and reduced quality of life in CAH. CaHASE2 was recently established to examine the current status of CAH care. We surveyed clinical practice in the UK and Ireland, and awareness and use of the International CAH (I-CAH) Registry.Methods: We undertook an anonymised online survey targeting clinicians provi...