Searchable abstracts of presentations at key conferences in endocrinology

ea0101op-04-05 | Oral Session 4: Young Investigators/Basic | ETA2024

Investigating the role of DICER1 in thyroid tumorigenesis

Rojo Maria , Godefroid Ludivine , Dom Genevieve , Lefort Anne , Libert Frederick , Maenhaut Carine

The abnormal expression of miRNAs has been linked to the development of multiple tumors, including thyroid tumors 1,2. Dicer1 is an essential enzyme for the biogenesis of microRNAs that has been found to be dysregulated in various cancers, notably, its expression is decreased in papillary thyroid carcinoma (PTC) 3,4. Multiple studies suggest Dicer1 as haploinsufficient tumor suppressor gene: while the loss of one allele promotes tumorigenesis, the complet...

ea0084op-07-34 | Oral Session 7: Thyroid Cancer Basic | ETA2022

CDK4 phosphorylation status and rational use of CDK4/6 inhibitors in advanced thyroid cancers

Pita Jaime M , Coulonval Katia , Costante Giuseppe , Myriam Decaussin , Emmanuelle Leteurtre , Cavaco Branca , A Copland John , Durante Cosimo , Maenhaut Carine , Dumont Jacques , Roger Pierre , Raspe Eric

Introduction and objectives: The cyclin-dependent kinases CDK4 and CDK6 are key regulators of the cell cycle entry, by phosphorylating the onco-suppressor retinoblastoma protein (pRb). CDK4/6 inhibitors (CDK4i) are already established as standard first-line treatment against advanced Estrogen Receptor-positive breast tumors, and have emerged as novel drugs to treat various pRb-proficient chemotherapy-resistant cancers. Presence of activating T172-phosphorylation of CDK4 in bre...

ea0084ps1-04-33 | Thyroid Hormone Transporters and Development | ETA2022

Transcriptomic signature of human embryonic thyroid reveals transition from differentiation to functional maturation

Dom Genevieve , Dmitriev Petr , Lambot Marie-Alexandra , Van Vliet Guy , Glinoer Daniel , Libert Frederick , Lefort Anne , E. Dumont Jacques , Maenhaut Carine

The human thyroid gland acquires a differentiation program as early as weeks 3–4 of embryonic development. The onset of functional differentiation, which manifests by the appearance of colloid in thyroid follicles, takes place during gestation weeks10–11. By 12–13 weeks functional differentiation is accomplished and the thyroid is capable of producing thyroid hormones although at a low level. During maturation, thyroid hormones yield increases and physiological ...