Searchable abstracts of presentations at key conferences in endocrinology

ea0081p526 | Adrenal and Cardiovascular Endocrinology | ECE2022

Testosterone, hypogonadism, and heart failure: a systematic and critical review

Di Lodovico Elena , Facondo Paolo , Delbarba Andrea , Chiara Pezzaioli Letizia , Maffezzoni Filippo , Cappelli Carlo , Ferlin Alberto

Background: Male hypogonadism is defined by low circulating testosterone level associated with signs and symptoms of testosterone deficiency. Although the bidirectional link between hypogonadism and cardiovascular disease has been clarified recently, the association between testosterone and chronic heart failure (CHF) is more controversial. Methods: We critically review published studies relating to testosterone, hypogonadism, and CHF and provide practic...

ea0041ep738 | Neuroendocrinology | ECE2016

The effects of pituitary replacement therapies on body composition in adult patients with growth hormone deficiency

Frara Stefano , Maffezzoni Filippo , Formenti Anna Maria , Mezzone Monica , Ferreira Caroline Ronchini , Doglietto Francesco , Maroldi Roberto , Mazziotti Gherardo , Giustina Andrea

Growth hormone deficiency (GHD) has become increasingly recognized as a cause of metabolic syndrome, characterized by altered body composition and adverse cardiovascular risk. The effects of other pituitary hormone deficiencies or their replacement therapies on the metabolic profile in this clinical setting are still largely unclear. In this study, we aimed to evaluating the effects of replacement therapies of central hypoadrenalism and hypothyroidism on body composition in a ...

ea0037ep813 | Pituitary: clinical | ECE2015

Cone beam computed tomography reveals altered trabecular bone structure in acromegaly

Giustina Andrea , Mazziotti Gherardo , Maddalo Michele , Maffezzoni Filippo , Frara Stefano , Zorza Ivan , Soldini Pierantonio , Doglietto Francesco , Maroldi Roberto

Over the last years, there has been evidence that acromegaly may cause skeletal fragility with high risk of vertebral fractures. The diagnostic approach to this complication is still a matter of uncertainty, since DXA measurement of bone mineral density (BMD) does not provide reliable information on fracture risk in acromegaly. The cone beam computed tomography (CBCT) technique offers three-dimensional images for the radiographed area with the advantage to use non-dedicated eq...

ea0049oc10.3 | Bone & Calcium Homeostasis | ECE2017

High prevalence of radiological vertebral fractures in patients with differentiated thyroid carcinoma undergoing L-thyroxine TSH-suppressive therapy

Formenti Anna Maria , Mazziotti Gherardo , Frara Stefano , Maffezzoni Filippo , Doga Mauro , Bertagna Francesco , Maroldi Roberto , Memo Maurizio , Giubbini Raffaele , Giustina Andrea

Thyroid hormones play a central role in the regulation of bone turnover and thyrotoxicosis is an established cause of secondary osteoporosis. Increased prevalence of reduced bone mineral density (BMD) has been reported even in patients with subclinical thyrotoxicosis such as those with differentiated thyroid carcinoma undergoing long-term L-thyroxine (L-T4) TSH-suppressive therapy. Morphometric vertebral fractures (VFs) are an early and clinically...

ea0041ep886 | Pituitary - Clinical | ECE2016

Radiological vertebral fractures in patients with acromegaly treated with L-thyroxine

Maffezzoni Filippo , Frara Stefano , Maria Formenti Anna , Mezzone Monica , Cerri Luigi , Porcelli Teresa , Doglietto Francesco , Maroldi Roberto , Mazziotti Gherardo , Giustina Andrea

Acromegaly is associated with skeletal fragility and high risk of vertebral fractures (VFs), but the determinants of such a risk are still under investigation and it is not clear whether replacement therapies of coexistent hypopituitarism may influence prevalence and incidence of VFs. In this cross sectional study, fourty acromegaly patients (24 M, 16 F; median age, 57 years; range, 25–72), 20 with active disease, were evaluated for the effects of replacement therapy of c...

ea0070aep133 | Bone and Calcium | ECE2020

Prevalence and determinants of radiological vertebral fractures in a cohort of patients with Klinefelter syndrome

Vena Walter , Pizzocaro Alessandro , Amer Myriam , Indirli Rita , Maffezzoni Filippo , Ferrante Emanuele , Delbarba Andrea , Balzarini Luca , Ferlin Alberto , Mantovani Giovanna , Lania Andrea , Mazziotti Gherardo

Klinefelter syndrome (KS) is a frequent form of male hypogonadism that may be associated with a series of comorbidities potentially affecting quality of life and survival. As a matter of fact, KS was shown to negatively impact skeletal health. However, the studies so far published on this topic were mainly focused on evaluation ofbone mineral density (BMD) and bone microstructure, whereas data on fracture risk are still lacking. In this cross-sectional study, we evaluated for ...

ea0070aep145 | Bone and Calcium | ECE2020

Prevalence of osteoporosis, vertebral fractures and hypogonadism in HIV-infected men.

Chiara Pezzaioli Letizia , Porcelli Teresa , Maffezzoni Filippo , Facondo Paolo , Di Lodovico Elena , Delbarba Andrea , Properzi Martina , Cappelli Carlo , Castelli Francesco , Eugenia Quiros Roldan Maria , Ferlin Alberto

With HAART (Highly Active Anti-Retroviral Therapy) introduction, HIV infection history has radically changed. Increased survival has led to new complications, including osteoporosis. The pathogenesis of osteoporosis in HIV patients is multifactorial: virus, HAART, smoking, alcohol, physical inactivity, comorbidities, and hypogonadism can interact in bone depletion.Aim of this study was to evaluate the prevalence of osteoporosis, vertebral fractures (VF) ...

ea0090p578 | Calcium and Bone | ECE2023

Assessment of dxa derived bone geometry parameters in early breast cancer patients: a cross-sectional study

Vena Walter , Pedersini Rebecca , Cosentini Deborah , Rinaudo Luca , Zamparini Manuel , Massimo Ulivieri Fabio , Mauro Pierluigi Di , Maffezzoni Filippo , Monteverdi Sara , Laini Lara , Amoroso Vito , Lucia Simoncini Edda , Farina Davide , Gerardo Lania Andre , Berruti Alfredo , Mazziotti Gherardo

Introduction: Bone mineral density (BMD) is considered a valid surrogate of bone strength in postmenopausal women, however it lacks sensitivity in individual fracture risk assessment in the setting of women with early breast cancer (EBC) patients treated with aromatase inhibitors (AIs). Indeed, mechanical resistance of bone only partially depends on bone quantity, and bone geometry and size play an important role in bone resistance to fractures. In this cross-sectional study, ...

ea0070aep562 | Pituitary and Neuroendocrinology | ECE2020

Treatment of acromegalic osteopathy in the real-life clinical practice: The baac (bone active drugs in acromegaly) multicenter study

Mazziotti Gherardo , Battista Claudia , Chiloiro Sabrina , Maffezzoni Filippo , Ferrante Emanuele , Grottoli Silvia , Grasso Ludovica , Gatto Federico , Olivetti Roberto , Arosio Maura , Bianchi Antonio , Carosi Giulia , Cellini Miriam , Chiodini Iacopo , De Marinis Laura , Di Somma Carolina , Ferlin Alberto , Ghigo Ezio , Lavezzi Elisabetta , Mantovani Giovanna , Pivonello Rosario , Porcelli Teresa , Prencipe Nunzia , Procopio Massimo , Scillitani Alfredo , Lania Andrea

Osteopathy is an emerging complication of acromegaly, characterized by increased bone turnover, profound abnormalities in trabecular bone structure and high risk of vertebral fractures (VFs). The therapeutic management of skeletal fragility in acromegaly is a challenge, since the risk of fractures may remain high after the control of acromegaly and the effectiveness of bone-active drugs in this clinical setting is unknown. In this retrospective-multicenter study, we aimed at e...