Searchable abstracts of presentations at key conferences in endocrinology

ea0081oc2.4 | Oral Communications 2: Adrenal and Cardiovascular Endocrinology 1 | ECE2022

Autonomous cortisol secretion in adrenal incidentalomas and risk of fragility fractures: a large cross-sectional study

Zavatta Guido , Vicennati Valentina , Altieri Paola , Colombin Giacomo , Coscia Kimberly , Fanelli Flaminia , Malagrino1 Matteo , Magagnoli Matteo , Tucci Lorenzo , Pagotto Uberto , Di Dalmazi Guido

Context: Autonomous cortisol secretion (ACS) has been associated with a higher prevalence of osteoporosis and fragility fractures in several studies. However, the data rely on heterogeneous studies and criteria for osteoporosis screening in this population are still debated.Objective: To assess the prevalence of fragility fractures and contributing factors in a large cohort of patients with adrenal incidentalomas.Methods: We review...

ea0081p273 | Adrenal and Cardiovascular Endocrinology | ECE2022

Salivary profiles of cortisol and cortisone in patients with primary adrenal insufficiency under replacement therapy: a pilot study

Tucci Lorenzo , Vicennati Valentina , Magagnoli Matteo , Colombin Giacomo , Coscia Kimberly , Rotolo Laura , Fanelli Flaminia , Pagotto Uberto , Di Dalmazi Guido

Background: Evaluation of steroid replacement therapy (SRT) in adrenal insufficiency (AI) is challenging for the lack of reliable parameters. Measurement of salivary cortisol and cortisone emerged as a non-invasive tool for AI management, however poorly investigated. Aim: To analyse the cortisol and cortisone circadian rhythm in normal controls (NC) and patients with primary AI (PAI) under different SRTs, and to identify useful biomarkers. <p class="...

ea0081ep860 | Reproductive and Developmental Endocrinology | ECE2022

A 20-steroid LC-MS/MS panel to investigate classical and backdoor pathways of androgen biosynthesis in the Leydig cells

Magagnoli Matteo , Mezzullo Marco , Limoncella Silvia , Tommasini Alessia , Santi Daniele , Pelusi Carla , Simoni Manuela , Pagotto Uberto , Casarini Livio , Fanelli Flaminia

Background: The classical steroidogenic route to the synthesis of dihydrotestosterone in Leydig cells involves delta-5 and delta-4 precursors. Besides, the “backdoor pathway”, encompassing progesterone metabolites, is gaining increasing interest in fetal development and men pathophysiology. Nowadays, liquid chromatography/tandem mass spectrometry (LC-MS/MS) is the ideal technique to simultaneously quantify large panels of steroids with elevated sensitivity and specif...

ea0081ep879 | Reproductive and Developmental Endocrinology | ECE2022

Daytime salivary androgen rhythm by LC-MS/MS in women affected by Polycystic Ovary Syndrome (PCOS) fulfilling the three Rotterdam diagnostic criteria

Fanelli Flaminia , Hawley James M , Mezzullo Marco , Fazzini Alessia , Zanotti Laura , Magagnoli Matteo , Pagotto Uberto , Keevil Brian , Gambineri Alessandra

Background: Excess testosterone in PCOS is accompanied by increased levels of other ovarian and adrenal androgens and precursors. Recently, 11-oxygenated adrenal androgens have been postulated as major components of the circulating androgen pool in PCOS. Obesity is strictly connected with androgen excess and with the derangement of hormone circadian rhythmicity. To date, it has not been clarified whether hyperandrogenism in PCOS, either complicated by obesity or not, is accomp...

ea0081rc13.5 | Rapid Communications 13: Adrenal and Cardiovascular Endocrinology 2 | ECE2022

Skeletal muscle mass in patients with adrenal incidentaloma

Colombin Giacomo , Vara Giulio , Fanelli Flaminia , Magagnoli Matteo , Tucci Lorenzo , Coscia Kimberly , Mosconi Cristina , Pagotto Uberto , Vicennati Valentina , Di Dalmazi Guido

Background and aim: The relationship between sarcopenia and overt cortisol excess as in Cushing’s syndrome is well-known. However, only a few studies investigated the relationship between autonomous cortisol secretion (ACS) in adrenal incidentalomas and skeletal muscle mass. The aims of our study were to analyze the skeletal muscle mass in patients with adrenal incidentalomas and to investigate the correlations with hormonal data.Methods: We enrolle...

ea0081p193 | Reproductive and Developmental Endocrinology | ECE2022

Efficacy of very low calorie ketogenic diet in obese PCOS: a randomized controlled study

Pandurevic Srdjan , Dionese Paola , Mancini Ilaria , Mitselman Dmitri , Magagnoli Matteo , Teglia Rita , Gazineo Domenica , Godino Lea , Fanelli Flaminia , Cristina Meriggiola Maria , Pagotto Uberto , Gambineri Alessandra

Background: Very low-calorie ketogenic diet (VLCKD) was shown to be effective in reducing weight and insulin resistance (IR) in obese patients. Considering that IR is very common in women with polycystic ovary syndrome (PCOS), and that IR worsens hyperandrogenism, ovulatory disfunction, and body fat accumulation, conceivably VLCKD could alleviate PCOS manifestations in the obese phenotype.Objective: This study compared the effects of a commercial VLCKD (...