Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep871 | Clinical case reports - Pituitary/Adrenal | ECE2017

Adipsic diabetes insipidus – a diagnostic and therapeutic challenge

Magalhaes Daniela , Esteves Cesar , Costa Maria Manuel , Rodrigues Pedro , Carvalho Davide

Introduction: In diabetes insipidus (DI) the serum sodium is often in the high normal range, required to provide the ongoing stimulation of thirst to replace the urinary losses. Marked hypernatremia can occur if a central lesion impairs both ADH release and thirst.Case report: A 57-year-old woman presented with dysuria, polyuria and fever. She was medicated with ciprofloxacin, however, she maintained symptoms, accompanied in the next day by nausea, vomit...

ea0049ep872 | Clinical case reports - Pituitary/Adrenal | ECE2017

Endosalpingiosis – re-thinking risk tumours in acromegaly

Magalhaes Daniela , Bettencourt-Silva Rita , Leitao Patricia , Morgado Paulo , Souto-Moura Conceicao , Carvalho Davide

Introduction: There is circumstantial evidence supporting a role of growth hormone and insulin-like growth factor 1 in the development and progression of tumors. Endosalpingiosis is characterized by the presence of non-neoplastic fallopion tube-like epithelium in ectopic anatomical locations.Case report: A 45-year-old woman presented with a constant moderate to intense perianal pain limiting basic daily life activities. She also complained about pain at ...

ea0041ep282 | Clinical case reports - Pituitary/Adrenal | ECE2016

Cyclic Cushing’s syndrome – a diagnostic challenge

Magalhaes Daniela , Bettencourt-Silva Rita , Queiros Joana , Freitas Paula , Vinha Eduardo , Pignatelli Duarte , Pereira Josue , Carvalho Davide

Introduction: The diagnosis of CushingÂ’s syndrome is often challenging considering that none of the used laboratory tests has an ideal diagnostic accuracy. The complexity of the diagnosis increases in cyclic disorder, which is characterized by repeated episodes of cortisol excess followed by periods of normal cortisol secretion.Case report: A 32-year-old woman with history of arterial hypertension and obesity presented with weight gain, hirsutism, a...

ea0041ep634 | Endocrine tumours and neoplasia | ECE2016

Hypoglycaemia unawareness – a challenge in the management of a Von Hippel-Lindau patient

Bettencourt-Silva Rita , Souteiro Pedro , Magalhaes Daniela , Oliveira Joana , Bessa de Melo Renato , Costa Maia Jose , Carvalho Davide , Queiros Joana

Background: The key physiologic defences against hypoglycaemia are the decrease in insulin and the increased secretion of glucose counterregulatory hormones, namely glucagon and epinephrine. The absence of warning signs of impending neuroglycopenia is known as hypoglycaemic unawareness.Case report: Male, 26 year-old, without relevant medical history and with normal body mass index, presented with hypertension, palpitations and diaphoresis. Clinical suspi...

ea0049ep140 | Clinical case reports - Pituitary/Adrenal | ECE2017

Virilization – a non-negligible manifestation of an adrenal tumor

Magalhaes Daniela , Vinha Eduardo , Neves Joao Sergio , Souteiro Pedro , Neves Celestino , Freitas Paula , Maia Jose Costa , Rios Elisabete , Fernandes Ana Catarina , Rodrigues Elisabete , Carvalho Davide

Introduction: Adrenocortical carcinoma (ACC) is a rare and aggressive endocrine malignancy with a poor prognosis. Hormone-secreting ACC appear with manifestations of virilization, feminization or Cushing syndrome.Case Report: A 63-year-old woman with no pathological history of relief was referred to Endocrinology evaluation with an history of deepening of the voice since 1-year ago, as well as hair loss and facial and abdominal hirsutism with 6-month evo...

ea0049ep477 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Lack of postpartum reclassification test in gestational diabetes – factors conditioning loss of follow-up

Bettencourt-Silva Rita , Souteiro Pedro , Magalhaes Daniela , Belo Sandra , Oliveira Ana , Carvalho Davide , Queiros Joana , Queiros Diabetes and Pregnancy Study Group Portuguese Society of Diabetology

Introduction: Gestational diabetes mellitus (GDM) is a risk factor for maternal-fetal complications and development of diabetes or intermediate hyperglycemia after pregnancy. The follow-up should be done by a multidisciplinary team. After delivery, all women diagnosed with GDM should undergo an oral glucose tolerance test (OGTT) for reclassificationAim: To evaluate the non-adherence factors to reclassification OGTT after GDM.Method...

ea0049ep564 | Diabetes complications | ECE2017

Small for gestational age and gestational diabetes – Should we be more permissive?

Bettencourt-Silva Rita , Souteiro Pedro , Magalhaes Daniela , Belo Sandra , Oliveira Ana , Carvalho Davide , Queiros Joana , Diabetes and Pregnancy Study Group Portuguese Society of Diabetology

Introduction: Gestational diabetes mellitus (GDM) is a risk factor for large for gestational age (LGA) newborns. The optimization of glycemic control and weight gain restriction during pregnancy according to BMI has contributed to decrease LGA but may increase the risk of small for gestational age (SGA).Aim: To evaluate the predictors of SGA in women with DGM.Methods: A cohort of 5271 Portuguese women from the National Registry of ...

ea0049ep630 | Diabetes therapy | ECE2017

Determinants of patient’s adherence and its relation to therapeutic success after hospital admission for decompensated diabetes

Magalhaes Daniela , Saavedra Ana , Souteiro Pedro , Bettencourt-Silva Rita , Costa Maria Manuel , Castedo Jose Luis , Freitas Paula , Nogueira Claudia , Queiros Joana , Carvalho Davide

Introduction: Diabetes mellitus (DM) is a chronic disease that requires continuous medical care. Health care providers should adopt approaches that improve patient outcomes and adherence.Aims: To evaluate the adherence to Endocrinology ambulatory follow-up after elective hospital admission for decompensated DM and to determine the relationship between adherence and therapeutic success after discharge.Methods: Retrospective study of...

ea0041gp59 | Cardiovascular endocrinology | ECE2016

Familial partial lipodystrophy type 3 due to PPARgamma mutation: presentation with diabetes and severe hypertriglyceridemia

Oliveira Joana , Cunha Filipe , Rodrigues Elisabete , Menezes Joana , Saavedra Ana , Costa Maria Manuel , Magalhaes Daniela , Bettencourt-Silva Rita , Fernandes Susana , Oliveira Joao Paulo , Carvalho Davide , Freitas Paula

Introduction: Familial partial lipodystrophy (FPL) is an autosomal dominant disease characterized by selective loss of subcutaneous fat from the extremities and gluteal region, with lipohypertrophy of the face, neck and trunk. It is usually tightly linked with severe metabolic complications. FPL type 3 results from peroxisome proliferator-activated receptor gamma (PPARG) mutations.Case presentations: Fifty three-year-old woman, referred to endocrinology ...

ea0041ep328 | Clinical case reports - Thyroid/Others | ECE2016

Diabetic gastroparesis – a pregnancy in jeopardy

Magalhaes Daniela , Bettencourt-Silva Rita , Costa Maria Manuel , Saavedra Ana , Belo Sandra , Queiros Joana , Freitas Paula , Namora Gabriela , Montenegro Nuno , Carvalho Davide

Introduction: Diabetic gastroparesis (DGP) is defined by delayed gastric emptying in the absence of mechanical obstruction caused by autonomic neuropathy. Only 5% of type 1 and 1% of type 2 diabetic patients combine the delay of gastric emptying with typical gastroparesis symptoms. This entity is usually identified in patients with least 10 years of diabetes evolution and is presented typically in the 4th to 5th decades of life in type 1 diabetes mellitus (T1DM). It is associa...