Searchable abstracts of presentations at key conferences in endocrinology

ea0014oc7.2 | Reproductive endocrinology I | ECE2007

Neuropilin-2 and its ligands are involved in the migration of GnRH-secreting neurons

Cariboni Anna , Rakic Sonja , Hickok Jason , Andrews William , Tischkau Shelley , Maggi Roberto , Parnavelas John

Reproduction in mammals is centrally regulated by neuroendocrine neurons scattered in the hypothalamus and secreting the decapeptide GnRH (gonadotropin releasing hormone). During development, GnRH-secreting neurons originate in the olfactory placode – at least in rodents – and migrate along olfactory nerves (the vomeronasal and the terminalis) to gain access to the forebrain and reach their final destinations in the hypothalamus. Defects in the migration of these neu...

ea0014oc11.2 | Reproductive endocrinology II | ECE2007

Leukemia inhibitory factor promotes the chemomigration of immature GnRH neurons

Dozio Elena , Ruscica Massimiliano , Cariboni Anna , Watanobe Hajime , Motta Marcella , Maggi Roberto , Magni Paolo

Leukemia inhibitory factor (LIF), a pleiotropic cytokine of the interleukine-6 superfamily, is involved in several functions including the control of reproduction at the embrionic-endometrial interface and the regulation of energy homeostasis. LIF activates a cell-surface receptor complex (LIF-Rs) composed of one ligand-specific low affinity LIF receptor β (LIFRβ) subunit and the gp130 subunit. Since little is known about the involvement of LIF in the modulation of t...

ea0020oc3.3 | Reproduction/Stress/Endocrine Disruptors | ECE2009

ESE Young Investigator Award

Bonomi Marco , Libri Domenico , Antonica Francesco , Busnelli Marta , Beck-Peccoz Paolo , Maggi Roberto , Krausz Csilla , Persani Luca

Idiopathic central hypogonadism (ICH) is a rare and heterogeneous disease due to defects of GnRH secretion or action. Depending on the association with a normal or defective sense of smell, ICH could be respectively identified as normosmic ICH (nICH) or Kallmann’s syndrome (KS). Recent experimental evidences indicate the involvement of the new PROK2/PROKR2 pathway in GnRH neuron maturation and function and mutations affecting these two genes have been described in some IC...

ea0016p398 | Neuroendocrinology | ECE2008

Genetic and clinical analyses in an Italian series of idiopathic hypogonadotropic hypogonadism

Bonomi Marco , Antonica Francesco , Cariboni Anna , Busnelli Marta , Pia Anna , Borretta Giorgio , Beck-Peccoz Paolo , Krausz Csilla , Maggi Roberto , Persani Luca

Idiopathic hypogonadotropic hypogonadism (IHH) is a rare and heterogeneous disease due to defects of GnRH secretion or action. IHH could be associated or not with anosmia respectively identifying the Kallmann’s syndrome (KS) or the normosmic IHH (nIHH). So far numerous causative genetic defects have been described, but very recent molecular genetic studies and animal models have opened novel perspectives. We are studying a series of 16 KS (14M,2F) and 18 nIHH (14M,4F). Al...