Searchable abstracts of presentations at key conferences in endocrinology

ea0059s5.1 | Breast cancer | SFEBES2018

Diving into the dark matter of the breast cancer genome

Magnani Luca

Recent years have seen an increasing effort to decode the cancer genome. Most of the studies have focused on the coding genome to identify cancer driver genes. My group is interested in the role of the non-coding genome and its potential contribution to the drive transcriptional aberrations in breast cancer patients. To do so we use a wide-spectrum of techniques including genomic, epigenomics in patient-derived samples. I will present the results of a couple of studies in whic...

ea0054is13 | (1) | NuclearReceptors2018

Enhancers mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancer

Patten Darren K , Corleone Giacomo , Győrffy Balazs , Erdős Edina , Saiakhova Alina , Goddard Kate , Vingiani Andrea , Shousha Sami , Pongor Lőrinc Sandor , Hadjiminas Dimitri J , Schiavon Gaia , Barry Peter , Palmieri Carlo , Coombes Raul C , Scacheri Peter , Pruneri Giancarlo , Magnani Luca

The degree of intrinsic and interpatient phenotypic heterogeneity and its role in tumour evolution is poorly understood. Phenotypic divergence can be achieved via the inheritance of alternative transcriptional programs. Cell-type specific transcription is maintained through the activation of epigenetically-defined regulatory regions including promoters and enhancers. In this work, we annotated the epigenome of 47 primary and metastatic oestrogen-receptor (ERĪ±)-positive br...