Searchable abstracts of presentations at key conferences in endocrinology

ea0099ep1185 | Pituitary and Neuroendocrinology | ECE2024

Role of tolvaptan as a cost-cutter in hospitalized SIADH patients

Ramachandran Kirtanya , Mahamud Bashir , Mlawa Gideon

Background: SIADH is a condition characterized by excessive ADH secretion from the posterior pituitary in the absence of triggers like high plasma osmolality and low blood volume or low blood pressure. This leads to excessive and unwanted water retention and increase in the total body water content, though the plasma sodium levels are normal.Case: An 89 y/o gentleman was admitted after he sustained a fall at his home and was diagnosed with right neck of ...

ea0081p115 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Immunotherapy-induced Diabetes Mellitus is not uncommon

Bell Janessa , Bashir Mahamud , Rehmani Hassan , Mlawa Gideon

Background: Lung cancers are one of the leading causes of death worldwide which has resulted in an increase in immunotherapy, particularly immune checkpoint inhibitors (ICIs). Recent studies have shown induced endocrinopathies secondary to ICIs as a result of pancreatic beta cells, thyroid, and pituitary dysfunction.Aim: We aim to present an interesting case of Type 1 Diabetes mellitus secondary to immunotherapy. Pembrolizumab is used to treat melanoma, ...

ea0090ep565 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

A case report on hypertriglyceridemia induced pancreatitis

Hussein Furhana , Cheung Man-Yan , Mlawa Gideon , Bashir Mahamud

Introduction: Acute pancreatitis is an inflammatory disease of the pancreas that can lead to necrosis of the pancreas and if infected could lead to multi-organ failure. Common cause of acute pancreatitis are gallstones and excess alcohol consumption. Hypertriglyceridemia is becoming an increasing cause of acute pancreatitis and is diagnosed with serum triglyceride levels >1.7 mmol/l. It is associated with high morbidity and mortality.Case presentatio...

ea0090ep844 | Pituitary and Neuroendocrinology | ECE2023

A case report of pituitary macroadenoma presenting with visual disturbance due to suspected cataract

Hussein Furhana , Cheung Man-Yan , Mlawa Gideon , Bashir Mahamud

Introduction: Pituitary adenomas are benign tumours of the pituitary gland with an estimated prevalence rate of approximately 17%. Around 1 in 600 people have macroadenoma (>1cm) that can present with variety of visual problems classically as bitemporal hemianopia due to compression of the optic chiasm.Case presentation: 50-year-old male was admitted with 3months history of worsening headache and 4months of visual disturbances. Initially he was seen ...

ea0070aep419 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Clinical evidence of the cost effectiveness of bariatric surgery in management of type 2 diabetes mellitus and obesity to prevent associated co-morbidity

Bashir Mahamud , Patel Shrini , Jugnarain Davina , Mlawa Gideon

Introduction: Diabetes is a chronic condition which has become a major public health concern approaching epidemic proportions globally. Effective diabetes management often presents many challenges. Clinicians and patients often become overwhelmed by the need to address co-morbid chronic conditions in addition to patients’ diabetes-specific treatment goals. It is widely accepted that bariatric surgery can help improve health in a range of metabolic diseases, including T2D...

ea0081p493 | Thyroid | ECE2022

Rare presentation of thyrotoxicosis post CoVID-19 vaccination in acute setting

Mohan Megha , Mahamud Bashir , Bell Janessa , Nikookam Khash , Hossain Belayet , Rehmani Hassan , Mlawa Gideon

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 has led to unparalleled burden on national and global healthcare systems. Vaccines were viewed as way of combating Covid 19 pandemic. This led to development and implementation of vaccination programmes worldwide. Several vaccines have been approved for use in worldwide including Pfizer-BioNTech, Oxford-AstraZeneca vaccine and Moderna vaccine. Disturbingly, the speed at which these va...

ea0081p500 | Thyroid | ECE2022

Immune check point inhibitors- induced thyroid disorders -would you recognise them?

Gandhi Jegadeshwaran , Mahamud Bashir , Bell Janessa , Ahmed Ghada , Elshowaya Suhier , Rehmani Hassan , Nikookam Khash , Mlawa Gideon

Introduction: Development and progression of cancers is multifactorial encompassing several mechanisms that aid its proliferation. One of the hallmarks of cancer progression is inhibition of the immune system. Cancer cells can activate different immune checkpoint are pathways that harbour inhibitory or stimulatory mechanisms that enabled self-tolerance and assist with immune response. Through activation of immune checkpoint pathways cancers can suppress immune response against...

ea0090p518 | Thyroid | ECE2023

Cerebral Vascular Accident in a patient presenting with a Thyroid Storm

Mohamed Ayan , Bashir Mahamud , Ramachandran Kirtanya , Etbinah Lubna , Mohammed Mohammed , Roy Juthi , Mlawa Gideon

Thyroid storm is rare life-threatening clinical manifestation of endocrine dysfunction originating from excess level of thyroid hormone leading to hypermetabolic state with an incidence of 0.57-0.76/1000,000. The increase demand of metabolic activity subsequently induces, palpitations, dyspnoea, exercise intolerance and congestive heart failure. Most common cardiovascular manifestation of thyroid storm is tachycardia and atrial fibrillation occurs in up to 15% of patients. In ...

ea0090p529 | Thyroid | ECE2023

Myxoedma coma and NAFLD secondary to poorly controlled Hypothyrodism

Mohammed Mohammed , Mohamed Ayan , Mahamud Bashir , Abumedian Mohammed , Saeed Yousif , Musa Awadelgeed , Mlawa Gideon

Myxoedema Coma with NAFLD secondary to poorly controlled hypothyroidism. Myxoedema coma is defined as severe hypothyroidism leading to decreased mental status, hypothermia, and other symptoms related to slowing function in multiple organs. It can culminate in severe, longstanding hypothyroidism or be precipitated by acute stressors such as infection, and surgery in patients with poorly controlled hypothyroidism. Moreover, there is a strong correlation between poorly controlled...

ea0090ep113 | Adrenal and Cardiovascular Endocrinology | ECE2023

A case of autoimmune polyglandular syndrome type 2 unmasked after treating subclinical hypothyroidism

Bashir Mahamud , Oyesanya Ayodeji , Mohammed Mohammed , Mohamed Ayan , Etbinah Lubna , Ramachandran Kirtanya , Mlawa Gideon

Background: Autoimmune polyglandular syndrome type 2 is an autoimmune disorder that affects many hormone-producing (endocrine) glands. It is characterized by the presence of AddisonÂ’s disease along with autoimmune thyroid disease and/or type 1 diabetes. The initial presentation can be varied but some patient maybe present with subclinical hypothyroidism and later develop Addisonian crisis. The pathogenesis of Autoimmune polyglandular syndrome type 2 remains unclear, altho...