Searchable abstracts of presentations at key conferences in endocrinology

ea0009p111 | Endocrine tumours and neoplasia | BES2005

Dehydroepiandrosterone (DHEA) replacement enhances IGF-I generation in hypopituitary patients on growth hormone replacement

Brooke A , Kalingag N , Maher K , Walker D , Hinson J , Monson J

We have reported that serum DHEAS increases in growth hormone deficient (GHD) adults with intact ACTH reserve during GH replacement (GHR) in contrast with persisting low levels in ACTH-deficient GHD patients (Isidori et al. Clin Endo 2003:58:601). This was associated with a lower GH dose requirement in ACTH sufficient patients suggesting that DHEA may augment IGF-I generation. We have examined this hypothesis in a double blind placebo controlled trial of 30 hypopituitary femal...

ea0037gp.04.07 | Steroids | ECE2015

Differential regulation of 11β-hydroxysteroid dehydrogenase type 1 activity in patients with differing aetiologies of hypopituitarism

Behan Lucy Ann , Rogers Bairbre , Maher K , Taylor Norman F , Smith Diarmuid , Thompson Chris J , Monson John P , Agha Amar

Pituitary patients with different aetiologies of hypopituitarism exhibit differing phenotypes despite optimal replacement therapy. We hypothesised that differential regulation of the isoenzyme 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), which mediates the autocrine conversion of cortisone to cortisol in adipose tissues and liver may play a role.We prospectively studied 11β-HSD1 activity through analysis of 24 h urine cortisol/cortisone ...

ea0005p176 | Growth and Development | BES2003

Cessation of growth hormone (GH) results in loss of lean body mass and reduced accrual of bone mass in adolescents with severe GH deficiency- 2 year follow up

Carroll P , Drake W , Maher K , Metcalfe K , Savage M , Dunger D , Shaw N , Camacho-Hubner C , Monson J

Continuation of GH at final height in hypopituitary adolescents with severe GH-deficiency results in accrual of bone mass over 12 months. We report body composition and BMD in 7 of these patients who discontinued GH but continued to have observations over 24 months. Five males and 2 females were included (17.4plus/minus0.3, years, meanplus/minusSE), in this Ethics Commitee approved study. All had severe GH-deficiency with multiple pituitary hormone deficits on appropriate repl...