Searchable abstracts of presentations at key conferences in endocrinology

ea0014p278 | (1) | ECE2007

SMP30 is expressed in rat mammary gland and down-regulated by estradiol

Maia Cláudio JB , Santos Cecilia RA , Schmitt Fernando , Socorro Silvia

The SMP30 (Senescence Marker Protein 30) is involved in the maintenance of intracellular Ca2+ homeostasis and in the regulation of various Ca2+- dependent proteins. A suppressive effect on cell proliferation, DNA synthesis and on the expression of oncogenes in rat hepatoma cells overexpressing SMP30 has been reported recently suggesting it may have a role in cancer progression. High levels of SMP30 expression have been found in liver and kidney of rats bu...