Searchable abstracts of presentations at key conferences in endocrinology

ea0016p504 | Obesity | ECE2008

Plasma adrenomedullin positively correlates to body mass index, and significantly decreases after bariatric surgery

Clodi Martin , Vila Greisa , Riedl Michaela , Handisurya Ammon , Maier Christina , Morgenthaler Nils G , Luger Anton

Adrenomedullin is a vasoactive peptide originally discovered in extracts of human pheochromocytoma. It is highly expressed in plasma and adipose tissue of obese subjects and considered as a member of the adipokine family. Adrenomedullin inhibits adipogenesis under the transcriptional control of insulin. We determined plasma adrenomedullin concentrations in a cohort of 360 healthy subjects and found a very significant positive correlation to body mass index (BMI). In parallel, ...

ea0016p506 | Obesity | ECE2008

Cholinergic regulation of meal induced ghrelin and PYY release is impaired in obesity

Maier Christina , Riedl Michaela , Vila Greisa , Wolzt Michael , Clodi Martin , Ludvik Bernhard , Luger Anton

Ghrelin and PYY are gastrointestinal peptides involved in appetite regulation. The cholinergic part of the vagal nerve participate in the regulation of glucose and insulin levels. We aimed to examine the effects of the cholinergic antagonist atropine on ghrelin, PYY, glucose and insulin under basal conditions and after meal ingestion in lean and obese subjects. Eight lean and eight obese subjects received in a randomized, double-blind, placebo controlled crossover study design...

ea0014p243 | (1) | ECE2007

Fasting and postprandial plasma obestatin levels are reduced in obesity

Maier Christina , Haider Dominik , Vila Greisa , Riedl Michaela , Luger Anton , Wolzt Michael

Obestatin has recently been identified as a peptide derived from pre-proghrelin that opposes ghrelin effects on appetite and body weight in rodents. We studied the effect of food intake on both these hormones in obese and lean subjects and recorded in parallel the subjective sensations of satiety and hunger. Eight obese (two males and six females, BMI=31–52 kg/m2) and eight age- and sex-matched lean subjects (BMI=19–23 kg/m2) were randomized to ...

ea0016p505 | Obesity | ECE2008

Plasma osteopontin correlates with insulin resistance in obese subjects, but increases following bariatric surgery parallel to other markers of bone turnover

Riedl Michaela , Vila Greisa , Maier Christina , Handisurya Ammon , Shakeri-Manesch Soheila , Prager Gerhard , Wagner Oswald , Kautzky-Willer Alexandra , Clodi Martin , Luger Anton

Osteopontin (OPN) is a multifunctional glycoprotein implicated, among others, in bone metabolism, cardiovascular disease, diabetes and obesity. It promotes inflammation and insulin resistance. Osteopontin is elevated in the plasma and adipose tissue of obese subjects and decreases upon diet induced weight loss. Here we investigated the effect of bariatric surgery on plasma OPN concentrations in morbidly obese patients. 40 obese patients aged 43.1±1.8 years were recruited ...