ea0022p767 | Thyroid | ECE2010
Catalano Maria Graziella
, Pugliese Mariateresa
, Germano Antonina
, Poli Roberta
, Palestini Nicola
, Mainini Franco
, Fortunati Nicoletta
, Boccuzzi Giuseppe
A functional sodium iodide symporter (NIS) is essential for radioiodine treatment of thyroid cancer. Unfortunately, most of de-differentiated tumours as well as anaplastic thyroid cancers loss the ability to concentrate iodine. Loss of NIS expression usually depends on epigenetic modifications, suggesting the use of epigenetic drugs as promising tools for re-differentiation. Panobinostat (LBH589) is a novel deacetylase inhibitor, acting at nanomolar concentrations, currently i...