Searchable abstracts of presentations at key conferences in endocrinology

ea0032p533 | Endocrine tumours and neoplasia | ECE2013

Polymorphisms of the glucocorticoid receptor gene, as phenotype modifiers in patients with hormonally inactive adrenal adenomas

Acs Bence , Szappanos Agnes , Feldman-Kovacs Karolina , Liko Istvan , Majnik Judit , Acs Orsolya , Szucs Nikolette , Toth Miklos , Racz Karoly , Patocs Attila

Introduction: Altered sensitivity against glucocorticoids is partly influenced by polymorphisms (SNP) of the glucocorticoid receptor gene (GR). The aim of the present study was to extend our earlier study by inclusion and evaluation the role of the BclI and A3669G polymorphisms of the GR in patients with hormonally inactive adrenal adenomas.Description of methods: This is a retrospective, single-centre genetic association study The study included 99 pati...

ea0014p282 | (1) | ECE2007

Correlation of BclI, N363S and the ER22/23EK polymorphisms of the glucocorticoid receptor gene and bone mineral density in patients with endogenous and exogenous hypercortisolism

Szappanos Ágnes , Toke Judit , Boyle Belema , Majnik Judit , Varga Ibolya , Gláz Edit , Tóth Miklós , Rácz Károly

Objective: Genetic variation in the glucocorticoid receptor (GR) gene may be related to the clinical heterogenety and severity of the CushingÂ’s syndrome. BclI, N363S and ER22/23EK polymorphisms are the three most investigated polymorphisms within the GR gene, however, the importance and magnitude of their effect in hypercortisolemic states are unclear. The BclI and the N363S variants are associated with increased, while the ER22/23EK variant is associated with reduced glu...