Endocrine Abstracts

Introduction: Hyponatraemia is common biochemical abnormality in hospitalised patients and is difficult to manage in some cases. Tolvaptan is presently licensed in the UK for the treatment of hyponatraemia secondary to SIADH. We present our experience of using Tolvaptan.Cases: Patient 1 was admitted with sagittal sinus thrombosis. Over 9 days serum sodium dropped from normal to 121 mmol/l with biochemical evidence of SIADH. The patient was treated with T...

A 34-year-old Caucasian male with type 1 diabetes, diabetic nephropathy and secondary hyperparathyroidism was electively admitted for parathyroidectomy. He is on regular peritoneal dialysis and is on the renal transplant list.On admission his PTH was 215.3 and corrected calcium was 2.01. Other biochemical parameters remained stable. He uneventfully underwent a total parathyroidectomy. No implantation of any of the parathyroid glands was done. He did not ...

Introduction: Thyroid dermopathy usually takes the form of pre-tibial myxedema, which may rarely be caused by Hashimoto’s thyroiditis. We present an extreme variant of pre-tibial myxedema, called Elephantiasis nostras verruca (ENV), in a hypothyroid patient.Case: A 51-year-old woman presented with a progressively worsening growth on her left leg and reduced mobility, constipation, cold intolerance and severe self-neglect. She was slow to respond to ...

Introduction: Cranial diabetes insipidus (DI) is a rare presenting complication of acute myeloid leukaemia (AML) or myelodysplasia, usually associated with complex cytogenetics. We report the case of a patient previously treated with cytotoxic therapy who presented with DI and AML. Case report: A 39 year old male presented with a three month history of lethargy, fatigue, and breathlessness. He also reported a ten day history of acute onset polydipsia and polyuria. He had been ...