Searchable abstracts of presentations at key conferences in endocrinology

ea0088001 | Abstracts | BES2022

Exercise as a non-pharmacological intervention to protect pancreatic beta cells in patients with type 1 and type 2 diabetes

de Brachene Alexandra Coomans , Corentin Scoubeau , Anyishai E Musuaya , Angela Castela , Julie Carpentier , Vitalie Faoro , Malgorzata Klass , Miriam Cnop , Decio L Eizirik

Aim of the work: Diabetes is characterized by progressive loss of functional pancreatic beta cells. None of the therapeutic agents used to treat diabetes arrest this process and preventing beta cell loss remains a major unmet need. We have previously shown that serum from 8 young healthy males who exercised for 8 weeks protects human islets and human insulin-producing EndoC-βH1 cells from apoptosis induced by pro-inflammatory cytokines or the endoplasmic reticulum (ER) st...