Searchable abstracts of presentations at key conferences in endocrinology

ea0007p17 | Comparative endocrinology | BES2004

An appraisal of biochemical assessment of hypogonadism and bio-available testosterone in adult men

Malkin C , Morris P , Channer K , Jones T

Hypogonadism is difficult to confirm with standard assays. A large proportion of testosterone (T) is bound to sex hormone binding globulin (SHBG) and is biologically inert. Accurate measures of free and biological-available-testosterone (Bio-T) are largely unavailable. In this study we compared formulae calculated from the total testosterone (TT) and SHBG in their ability to predict hypogonadism and/or Bio-T.TT and SHBG were determined by ELISA and Bio-T...

ea0005p83 | Diabetes, Metabolism and Cardiovascular | BES2003

Testosterone is a dilator of resistance arteries in men with congestive heart failure

Malkin C , Pugh P , Jones R , Jones T , Channer K

BackgroundHeart failure is a syndrome of vaso-constriction and hormone abnormalities. There is an excess of catabolic and vasoconstrictor hormones and a relative deficiency of anabolic hormones. Vaso-dilating drugs improve symptoms in heart failure and inhibition of some catabolic / vasoconstrictor hormones improves prognosis. We aimed to study the direct vascular effects of testosterone resistance arteries from men with heart failure.Methods6 resistance arteries w...

ea0005p100 | Diabetes, Metabolism and Cardiovascular | BES2003

Treatment of coronary disease and effects on endogenous testosterone levels

Malkin C , Pugh P , Jones T , Channer K

Background. Males with coronary disease have lower levels of endogenous testosterone than unaffected males. It is not known if low testosterone is a cause, effect or an epi-phenomenon of ischaemic heart disease.We hypothesised that androgen deficient men treated surgically with complete resolution of their symptoms would have a higher subsequent testosterone than men with persistent angina.Methods. Subjects were recruited after angiography. All subjects were biochemically ...

ea0004p37 | Diabetes, metabolism and cardiovascular | SFE2002

Haemodynamic effects of acute buccal administration of testosterone in men with heart failure

Pugh P , Malkin C , Jones R , Channer K , Jones T

Background: Testosterone treatment has been shown to increase exercise capacity in men with chronic heart failure but the mechanism of benefit is unclear. The purpose of this study was to examine the acute haemodyamic effects of testosterone in men with heart failure.Methods: Twelve men with stable heart failure (age 62.8 (8.8)years; ejection fraction 30.9 (6.3)% (NR>60%)) were enrolled in a double-blind, placebo-controlled cross-over study. Cardiac o...

ea0009oc9 | Oral Communication 1: Diabetes and metabolism | BES2005

Testosterone improves funtional capacity and symptoms in men with chronic heart failure: a double blind placebo controlled trial

Malkin C , Pugh P , Jones R , van Beek E , West J , Channer K , Jones T

Chronic heart failure (CHF) is associated with maladaptive and prolonged neurohormonal and pro-inflammatory cytokine activation causing a metabolic shift favouring catabolism, vasodilator incapacity, and loss of skeletal muscle bulk and function. In men, androgens are important determinants of anabolic function and physical strength and also possess anti-inflammatory and vasodilatory properties. We conducted a randomised, double blind, placebo controlled trial of testosterone ...

ea0007p22 | Cytokines and growth factors | BES2004

The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men

Malkin C , Pugh P , Jones R , Kapoor D , Channer K , Jones T

Testosterone has immune-modulating properties and current in-vitro evidence suggests that testosterone may suppress the expression of the pro-inflammatory cytokines Tumour Necrosis Factor (TNF alpha), interleukin (IL)-1 beta and IL-6 and potentiate the expression of the anti-inflammatory cytokine IL-10. We report a randomised single-blind placebo-controlled crossover study of testosterone replacement (Sustanon 100) versus placebo in 27 men (age 62+-9years) with symptomatic and...

ea0005p225 | Steroids | BES2003

High prevalence of low testosterone levels in men with coronary heart disease and an association with hypertension and obesity - The South Yorkshire study

Pugh P , Morris P , Hall J , Malkin C , Asif S , Jones R , Channer K , Jones T

We(1) and others have established that men with coronary heart disease (CHD) have lower serum testosterone levels than men with normal coronaries. Hypotestosteronaemia is associated with dyslipidaemia, visceral obesity, insulin resistance, hypertension and a prothrombotic state.The aim of this study was to determine the prevalence of hypogonadism in men with CHD proven by either greater than 70 per cent stenosis of one or more epicardial or greater than 50 per cent stenosi...