Endocrine Abstracts

Introduction: Recent studies suggest that the use of dipeptidyl peptidase 4 inhibitors (DPP-4i) may be associated with an increased risk of developing bullous pemphigoid; which has led to publication of several pharmacovigilance alerts.Objectives: To characterize the potential association between the use of DPP-4i and the risk of developing bullous pemphigoid.Material & methods: Observational, retrospective study based on clini...

Objective: To study the GLP-1 pattern of secretion after an oral glucose tolerance test (OGTT) in women in postpartum reassessment of previous gestational diabetes (GDM). To evaluate clinical and laboratory parameters that can influence GLP-1 secretion.Patients and methods: Forty-eight women with a history of GDM were assessed one year after childbirth determining clinical and analytical characteristics and OGTT with 75 g. We measured glucose, insulin an...

Introduction: Adrenal masses are among the most frequent tumours in humans (ACT). A vast majority of these tumours are benign (ACAs). Only a small subset of adrenal masses are malignant adrenocortical carcinomas (ACCs). Tumour size, tumour weight, hormonal function and pathologic criteria are useful clinicopathological criteria that can result in accurate diagnosis of most ACCs and ACAs.Case report: 31-years-old woman, without relevant previous history. ...

Introduction: There is a reduction of the incretin effect in patients with type 2 diabetes secondary to altered secretion of incretin hormones and/or failed of its action.Objective: To study the GLP-1 secretion pattern after an oral glucose tolerance test (OGTT) in postpartum reassessment of women with previous GDM.Materials and methods: Prospective epidemiological study of 48 women with a history of GDM. We evaluated age, history ...

Background and objectives: The finding of a thyroid nodule is a very common occurrence in clinical practice. Management of thyroid nodules requires a multidisciplinary approach that may be eased by a high-resolution thyroid nodule clinic. We report our clinical experience and outcomes in a high-resolution thyroid nodule clinic.Materials and methods: We conducted a retrospective analysis of 1674 thyroid nodules evaluated in a high-resolution clinic from a...

We presented the case of a 21 years old patient, derived from Primary Care to evaluate low testosterone levels (total testosterone (TT) 0.44 ng/ml). His father had delayed pubety and his mother menarche was at 11 years. No other personal history of interest. He had adequate child development and vaccination. No parotiditis. He referred some morning erections. Weight 59 kg, size 171 cm and BMI 20.17 kg/m2. Testes volume (TV) of 4-5 cc, scanty pubic hair. Tanner stage...

Introduction: Somatostatin analogs (SS-analogs) are the treatment option when there is a persistent disease despite surgical intervention. They can be also recommended as a first line treatment if surgery is not appropriate (non-curative or contraindicated surgery).Objetive: To evaluate the effect of first-generation SS-analogs (lanreotide and octreotide) on tumour shrinkage and biochemical control in naive patients.Methods: We per...

Introduction: Percutaneous ethanol injection (PEI) or thyroid enolisation is a minimally invasive technique applicable to benign cystic thyroid nodules, not adhered to neighbouring structures, due to local compressive symptoms or aesthetic discomfort. Classically, the treatment of choice for these nodules has been simple aspiration, followed by surgery in refractory cases. Currently, PEI has emerged as an alternative to surgery due to its high efficacy, speed, safety, low rate...

An 18-years-old woman without medical history was referred for study of hypertension and an adrenal incidentaloma. The family history was significant for essential well-controlled hypertension in her father; diagnosed at 39 years-old. The patient complained of headache, asthenia, edema in lower limbs, high blood pressure values (200/150 mmHg) for one year (well controlled with losartan 100 mg/12 h, amlodipine 10 mg/24 h and doxazosin 4 mg/24 h) and marked facial acne previous ...

Introduction: Glycogenosis is a group of hereditary diseases affecting the glycogen metabolism, due to mutations in enzymes involved in the transformation and synthesis of glucose (liver and muscle glycogenosis). Brain germ tumors are very infrequent. They are located mainly in pineal and sellar region. Central diabetes insipidus is the most frequent manifestation. Their prognosis and response to combined chemo/radiotherapy treatment are favorable.Case r...