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Endocrine Abstracts

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ea0011p859 | Thyroid | ECE2006

Thyrotropin receptor (TSHR) activation has variable effects on the TNFα axis in preadipocyte and osteoblast-like cell lines

Mandrikoula M , Henry M , Evans BAJ , Ludgate M

In addition to its central role in the control of thyrocyte growth and function, the TSHR is expressed during the differentiation of mesenchymal precursors. To explore further, we have developed an in vitro model in which TSHR activation is achieved by introducing constitutively active (M453T, L629F) TSHR, using retroviral vectors.We aimed to investigate the effect of TSHR activation on body composition, via the production of TNFα and express...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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