Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep843 | Reproductive and Developmental Endocrinology | ECE2020

Hyperandrogenism in a postmenopausal woman secondary to an androgen secreting steroid cell tumor of the ovary

Bastos Filipa , Franco Sara , Ferreira Ana , Manita Isabel , Portugal Jorge

Introduction: Androgen secreting neoplasms of the ovary are rare and usually show autonomous secretion. Steroid cell tumors of the ovary represent less than 0.1% of all ovarian tumors and are a subgroup of sex cord-stromal tumors. In most cases, patients present with androgenic clinical features.Case report: A 58-year-old woman complained of rapid onset of androgenic alopecia, excessive hirsutism and clitoromegaly. Endocrine assessment showed high levels...

ea0055wa13 | Workshop A: Disorders of the hypothalamus and pituitary (I) | SFEEU2018

Cushing’s disease relapse associated with central diabetes insipidus

Ferreira Ana , Silva Tiago , Bastos Filipa , Manita Isabel , Cordeiro Maria Carlos , Portugal Jorge

Introduction: Central diabetes insipidus (DI) is a frequent complication of transfenoidal surgery for Cushing’s disease (CD). It can be transient or, more infrequently, permanent. The most common mechanism results from surgical neurohypophyseal damage rather than local mass effect from the pituitary adenoma.Case report: A 40 years old woman was referred to our Endocrinology outpatient clinic at the beginning of 2015 for new onset hypertension, signi...

ea0020p533 | Paediatric Endocrinology | ECE2009

Prevalence of autoimmune thyroiditis in children with diabetes mellitus

Veloza Andreia , Coelho Catarina , Manita Isabel , Cordeiro Maria , Passos Dolores , Raimundo Luisa , Portugal Jorge

Introduction: Type 1 diabetes mellitus (DM1) is frequently associated with other autoimmune diseases. Among children and adolescents, thyroid disease is the most common autoimmune endocrinopathy. The possibility of occult thyroid disease should be considered at diagnosis and when a patient is assessed at the annual review.Objective: The aim of our study was to determine the prevalence of autoimmune thyroiditis among children and adolescents with type 1 d...

ea0014p424 | (1) | ECE2007

Juvenile osteoporosis in untreated GH-deficient patient – is treatment with GH replacement indicated? A clinical case report

Coelho Catarina , Saraiva Catarina , Manita Isabel , Velosa Andreia , Passos Dolores , Carlos Maria , Raimundo Luisa , Portugal Jorge

Treatment for osteoporosis in children/adolescents is extremely important not only to improve bone quality but also because, if left untreated, could lead to severe and precocious loss of bone mass. Studies in growth hormone (GH) deficient adults, in turn, have shown that treatment with GH produce bone mass gain and improve the occurrence of both bone formation and reabsorption.The authors present the following case report of a 16 year old Caucasian fema...

ea0049ep486 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Insulin autoimmune syndrome: the relationship between insulin, c-peptide and glucose in active and recovering disease states

da Silva Tiago Nunes , Ferreira Ana Goncalves , Manita Isabel , Matos Ana Catarina , Carvalho Isabel , Font Paula , Prazeres Susana , Portugal Jorge

Insulin autoimmune syndrome (IAS) is a very rare cause of hypoglycaemia in western countries. One proposed mechanism is anti-insulin antibody capture of prandial insulin followed by the dissociation of insulin from anti-insulin antibody. The first objective was to study the relationship between glucose, insulin and C-peptide during a prolonged glucose load in two patients with active IAS. The second was to study the variation of these parameters between the active and the reco...

ea0014p480 | (1) | ECE2007

Bartter syndrome – a case of secondary hyperaldosteronism

Manita Isabel , Veloza Andreia , Coelho Catarina , Saraiva Catarina , Passos Dolores , Cordeiro Maria , Raimundo Luísa , Portugal Jorge

Introduction: Bartter syndrome represents a set of closely related autosomal recessive renal tubular disorders characterised by hypokalemia, hypochloremia, metabolic alkalosis and hyperreninemia with normal blood pressure. The underlying abnormality results in excessive urinary losses of sodium, chloride and potassium. Bartter syndrome is classified into 3 main clinical variants: neonatal Bartter syndrome, classic syndrome and Gitelman syndrome.Case repo...

ea0037gp.27.07 | Thyroid – hyperthyroidism and treatment | ECE2015

Plasmapheresis in thyroid storm caused by exogenous thyroid hormone intake: a case series

da Silva Tiago Nunes , Pereira Bernardo Dias , Luiz Henrique Vara , Macau Ricardo , Matos Ana Catarina , Manita Isabel , Bravo Pedro , Cordeiro Maria Carlos , Raimundo Luisa , Portugal Jorge

Thyroid storm (TS) is one extreme of a continuum beginning with thyrotoxicosis. It’s rarely caused by exogenous thyroid hormone intake (ETHI). Aggressive medical therapy is the cornerstone of treatment; nevertheless, it might not be sufficient. Plasmapheresis is an extracorporeal technique that can rapidly lower thyroid hormone levels. The aim of this study was to assess the efficacy of plasmapheresis in TS secondary to ETHI. We evaluated retrospectively all TS cases (Bur...

ea0035p58 | Adrenal Medulla | ECE2014

Pheochromocytomas and paragangliomas: association between tumor size and measurements of metanephrines and catecholamines

Luiz Henrique Vara , Silva Tiago Nunes da , Pereira Bernardo Dias , Veloza Andreia , Matos Ana Catarina , Manita Isabel , Cordeiro Maria Carlos , Raimundo Luisa , Portugal Jorge

Introduction: Pheochromocytomas (PHEO) and paragangliomas (PGL) are rare catecholamine-secreting tumors. Some authors proposed that there is a positive linear relationship between tumor size and measurements of metanephrines and an absence of association with catecholamine levels.Objectives: To review and characterize patients diagnosed with PHEO and PGL in Garcia de Orta Hospital. To determine the relationship between tumor size and measurements of urin...

ea0035p1136 | Thyroid Cancer | ECE2014

Prevalence and risk of malignancy of thyroid incidentalomas discovered by 18F-fluorodeoxyglucose positron emission tomography

da Silva Tiago Nunes , Luiz Henrique Vara , Pereira Bernardo Dias , Matos Ana Catarina , Manita Isabel , Carmona Susana , Santos Ana Isabel , Portugal Jorge

The use of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG–PET) has increased the detection of thyroid incidentalomas (TI). These are associated with a risk of malignancy between 25 and 50%. Some studies show an association between SUVmax uptake and malignancy.The objective of this study was to determine the prevalence of malignancy on 18F-FDG–PET positive thyroid nodules and to evaluate the relatio...

ea0070ep269 | Endocrine-related Cancer | ECE2020

Multiple endocrine neoplasia: A case series of 7 families

Duarte Vitória , Ivo Catarina , Veríssimo David , Marcelino Mafalda , Vara Luiz Henrique , Franco Sara , Bastos Filipa , Manita Isabel , Raimundo Luisa , Portugal Jorge

Introduction: Multiple endocrine neoplasia (MEN) is a rare genetic syndrome characterized by occurrence of tumors involving two or more endocrine glands. Four types are described: MEN1, MEN2, MEN3 and the recently identi&#-1279;ed MEN4. Due to the complexity of the syndromes, it is difficult to manage these patients. Our objective was to describe the clinical features of individuals from 7 families with a diagnosis of MEN1 or MEN2 and identify current challenges in clinical pr...