Searchable abstracts of presentations at key conferences in endocrinology

ea0014p110 | (1) | ECE2007

Thyroid cancer and pregnancy: clinical outcome and time of diagnosis in a series of 94 women

Michela Perrino , Guia Vannucchi , Leonardo Vicentini , Mannavola Deborah , Beck-Peccoz Paolo , Fugazzola Laura

Thyroid cancer represents the second more frequent tumor among those diagnosed during pregnancy. Indeed, during pregnancy thyroid volume increases by 20–30% and new nodules can appear, due to the effect of choriogonadotropin which stimulates thyroid growth. Hence, it has been proposed that thyroid cancer diagnosed during pregnancy could harbour a poorer prognosis. Aim of the present study was to compare the clinical outcome in the following 3 groups of patients affected w...

ea0016p765 | Thyroid | ECE2008

A prospective study on a large series of non toxic multinodular goiters treated with radioiodine: results at long term follow-up

Vannucchi Guia , Mannavola Deborah , Chiti Arturo , Dazzi Davide , Rodari Marcello , Tadayyon Sara , Beck-Peccoz Paolo , Fugazzola Laura

Radioiodine (131I) administration has been found to be effective in the treatment of hyperfunctioning and normofunctioning multinodular goiter. Moreover, lithium therapy has been shown to enhance the radioiodine efficacy and to reduce the transient thyrotoxicosis induced by radioiodine.Aim of the present study was to evaluate the long term efficacy of 131I with or without lithium administration in the treatment of non toxic multinod...

ea0014oc1.4 | Thyroid clinical | ECE2007

A novel tyrosine-kinases selective inhibitor with anti-tumoral efficacy (Sunitinib) induces a block in iodine uptake and transient hypothyroidism

Mannavola Deborah , Vannucchi Guia , Carletto Marco , Longari Virgilio , Bertuelli Rossella , Coco Paola , Casali Paolo , Beck-Peccoz Paolo , Fugazzola Laura

Sunitinib (SU11248) is a multitarget inhibitor of tyrosine-kinases (RTK) recently tested in clinical trials for the treatment of some human cancers. Side effects are mostly represented by asthenia and appear in a dose and time correlated manner. After the unexpected observation of a myxedematous coma in a patient affected with GIST and treated with Sunitinib, we evaluated the effect of this drug on thyroid function in 24 patients treated for GISTs Imatinib resistant. Patients ...

ea0016oc2.7 | Thyroid | ECE2008

Impact of resistance to thyroid hormone on the cardiovascular system in adult humans

Pulcrano Melania , Mannavola Deborah , Palmieri Emiliano A , Campi Irene , Ciulla Michele , Michi Riccardo , Ippolito Serena , Lombardi Gaetano , Biondi Bernadette , Beck-Peccoz Paolo

Background: Resistance to thyroid hormone (RTH) is an inherited condition of reduced tissue responsiveness to thyroid hormone (TH), biochemically characterized by elevated serum TH concentrations, with inappropriate, non-suppressed thyrotropin levels (TSH). It is caused by point mutations in the ligand binding domain of the TH receptor (TR) β gene, and the mutant TR interferes with the function of the normal TRs (dominant negative effect). The clinical manifestations of R...