Searchable abstracts of presentations at key conferences in endocrinology

ea0014p196 | (1) | ECE2007

Continuous administration of dihydrotestosterone or letrozole to immature female rats results in polycystic ovary syndrome characteristics at adult age

Mannerås Louise , Lystig Theodore , Holmäng Agneta , Ottosson-Lönn Malin , Stener-Victorin Elisabet

Introduction: Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder associated with ovulatory dysfunction, hyperandrogenism, abdominal obesity and insulin resistance. Since hyperandrogenism is a PCOS key feature, the aim was to evaluate the effects of androgen receptor activation in terms of continuously administration, beginning pre-pubertal, of either the non-aromatizable androgen dihydrotestosterone (DHT) or the aromatase inhibitor letrozole (L), on...