Searchable abstracts of presentations at key conferences in endocrinology


Cognitive impairment reversed by cinacalcet administration in primary hyperparathyroidism: a case report

Timmons Joseph , Manners Rachel , Bailey Matthew , McDougall Claire

An 87 year old lady with a background of longstanding cognitive impairment was referred to our service with biochemical evidence of primary hyperparathyroidism. The patient had past medical history of type 2 diabetes mellitus, osteoporosis, hypothyroidism, ischaemic heart disease and primary hyperparathyroidism (under observation in a neighbouring health board). There was no pharmacological cause for cognitive impairment identified. Following acute admission after a fall with ...

ea0007p105 | Endocrine tumours and neoplasia | BES2004

Imbalance between separase and securin levels in thyroid and other malignancies

Khanim F , Parmley J , Boelaert K , Stratford A , Manners A , Hodges N , McCabe C , Gittoes N , Franklyn J

Chromosomal instability (CIN) is a common feature of many malignancies including papillary and follicular thyroid cancer. During mitosis, there are multiple stages which, if dysregulated, may result in CIN. One critical stage is the regulation of sister-chromatid separation at the metaphase-anaphase transition. Three key protein complexes regulate this process: separase, cohesins and securin (also known as pituitary tumor transforming gene). In vivo, most tumours studied demon...