Searchable abstracts of presentations at key conferences in endocrinology

ea0081rc6.3 | Rapid Communications 6: Endocrine-Related Cancer | ECE2022

New epigenetic and functional features in pheochromocytoma

Manso Jacopo , Bertazza Loris , Barollo Susi , Censi Simona , Carducci Sofia , Mian Caterina

Background: Pheochromocytoma (Pheo) is a tumor deriving from chromaffin cells. It can be studied using 18F-dihydroxyphenylalanine (DOPA) - positron emission tomography (PET) due to its overexpression of L-type amino acid transporters (LAT1 and LAT2). The oncogenic pathways involved are still poorly understood. This study examined the relationship between 18F-DOPA-PET uptake and LAT1 expression, and explored the role of miR-375 and putative target genes.</...

ea0081ep1019 | Thyroid | ECE2022

The hobnail variant of papillary thyroid carcinoma: clinical/molecular characteristics of a large monocentric series and comparison with conventional histotypes

Censi Simona , Manso Jacopo , Paganin Francesco , Vianello Federica , Galuppini Francesca , Pennelli Gianmaria , Iacobone Maurizio , Bertazza Loris , Barollo Susi , Mian Caterina

Background: Hobnail variant of papillary thyroid carcinoma (HPTC) has been recently identified. Given the rarity of the variant its characteristics have been studied only in little series, limiting the quality of the data available for its better management. The aims of our retrospective study were 1) to define the clinical and molecular characteristics of a series of HPTC in a monocentric and relatively large series; 2) to define the clinical and molecular characteristics abl...

ea0081ep1063 | Thyroid | ECE2022

Therapeutic plasma exchange in amiodarone induced thyrotoxicosis: a case report

Clausi Cristina , Manso Jacopo , Graziani Andrea , Censi Simona , Carducci Sofia , Zhu Yi Hang , Piva Ilaria , Mian Caterina

A 52-year man came to Emergency Department with Atrial Fibrillation with rapid ventricular response due to amiodarone induced thyrotoxicosis (AIT). The patient was found tachi-arrhythmic (153 beats per minute), tachypnoic (27 breaths per minute) and with intense hyperidrosis. His first blood test documented thyroid stimulating hormone (TSH) <0.01 mUI/l, free triiodothyronine (fT3) 20.0 pmol/l and free thyroxine (fT4) over 100 pmol/l. Thyroid ultrasonography revealed an enl...

ea0084ps3-13-117 | Pregnancy & Iodine | ETA2022

Iodine status during pregnancy in the veneto region: impact on maternal and newborn thyroid function and analysis of the nutritional and socio-economic determinants

Censi Simona , Mondin Alberto , Messina Giulia , Pedron Mariachiara , Manso Jacopo , Faggian Diego , Basso Daniela , Bertazza Loris , Barollo Susi , Marin Loris , Camilot Marta , Andrisani Alessandra , Mian Caterina

Objectives: The aim was to evaluate the iodine nutritional status in pregnant women residing in Veneto region and its associations with diet, iodine supplements and social status (nationality and education).Methods: 292 consecutive pregnant women at the third trimester of pregnancy were enrolled (≥18 years old, and resident in Veneto). Exclusion criteria were a personal history of thyroid disease and the refusal of the informed consent. Every woman...

ea0070aep881 | Thyroid | ECE2020

The diagnostic value of basal and calcium-stimulated procalcitonin for the diagnosis of medullary thyroid cancer: Preliminary results from a multicentric experience

Censi Simona , Di Stefano Marta , Repaci Andrea , Manso Jacopo , Pagotto Uberto , Bertazza Loris , Barollo Susi , Plebani Mario , Colombo Carla , Fugazzola Laura , Mian Caterina

Background: Calcitonin (CT) is the most sensitive marker for MTC diagnosis. By the way, many pre-analytical, analytical and post-analytical pitfalls worsen its accuracy. Procalcitonin (proCT), a CT precursor, has been suggested as a valuable complementary test in MTC diagnosis, given its stability and the reproducibility between different assay kits.Material and Methods: basal CT (bCT) and proCT (bproCT) and stimulated CT (bCT) and proCT (sproCT) (2&#821...

ea0032p756 | Obesity | ECE2013

Circulating endocannabinoids are differentially modulated during the oral glucose tolerance test

Fanelli Flaminia , Garelli Silvia , Mezzullo Marco , Di Dalmazi Guido , Ponti Federico , Manso Jacopo , Benetta Elisa Dalla , Bazzocchi Alberto , Vicennati Valentina , Battista Giuseppe , Pasquali Renato , Pagotto Uberto

The endocannabinoid system (ECS) is involved in the regulation of food intake and energy expenditure. Increased level of EC lipid mediators anandamide (AEA) and 2-arachydonoylglycerol (2AG) and/or a higher expression of cannabinoid receptor type 1 in central and peripheral districts are supposed to contribute to the development and maintenance of obesity and related dismetabolism. To understand the ECS response to insulin signal and to anthropometric and biochemical parameters...

ea0063gp83 | Thyroid Nodules and Cancer | ECE2019

Prognostic significance of TERT promoter and BRAF mutations in cytologically suspicious or malignant thyroid nodules: a monocentric case series at a tertiary-level endocrinology unit

Censi Simona , Barollo Susi , Grespan Elisabetta , Watutantrige-Fernando Sara , Cavedon Elisabetta , Manso Jacopo , Iacobone Maurizio , Ide Eric Casal , Galuppini Francesca , Fassina Ambrogio , Pennelli Gianmaria , Vianello Federica , Bertazza Loris , Mian Caterina

Background: Follicular-derived thyroid cancers (FDTC) generally have a good prognosis. Nonetheless, a minority of them have an aggressive behavior and develop distant metastases, with increased mortality rates. Pre-surgically available prognostic markers, able to identify this group of patients are still lacking.Materials and methods: The study involved 436 FNA samples with a malignant/suspicious cytology obtained from thyroid nodules in 436 consecutive ...