Searchable abstracts of presentations at key conferences in endocrinology

ea0041s8.2 | Primary aldosteronism | ECE2016

Revised guidelines for finding and treating primary aldosteronism

Mantero Franco

Primary aldosteronism is an endocrine form of hypertension which is highly prevalent among hypertensive population but its rate of detection is far lower than its real prevalence.This might be due to lack of adequate information or expertise in general practitioners or even among hypertension specialists, other than endocrinologists. As PA is common, and has a much higher cardiovascular risk profile than age-, sex-, and blood pressure (BP)–matched e...

ea0016me5 | (1) | ECE2008

How valid is a biochemical diagnosis of chromaffin tumors?

Mantero Franco

Phaeochromocytoma (PH) and functional paraganglioma (FPGL) are neoplasm of chromaffin tissue that synthesise catecholamines and are mostly located in adrenal medulla (PH) or elsewhere (FPGL). Patients may also harbour non-secreting head and neck paragangliomas (PGL). Up to ¼ of PH/PGL are familial. A high degree of suspicion for PH and FPGL should be risen in case of spells, resistant hypertension, family history of PH/PGL, a genetic syndrome that predispose to PH (e.g. M...

ea0016p148 | Clinical cases | ECE2008

A case of hungry bone syndrome during therapy with methimazole for hyperthyroidism

Sanguin Francesca , Camozzi Valentina , Mantero Franco , Luisetto Giovanni

We describe a case of severe hypocalcemia after methimazole treatment for Graves disease, which closely resembles classic hungry bone syndrome.A 41-year-old woman with a history of Graves disease presented to our Internal Medicine ward with tachyarrythmia. Laboratory data showed a severe hyperthyroidism, an ecocardigraphy demonstrated a dilated cardiomyopathy. The patient was given beta-blockers, low molecular weight heparin, and methimazole (30 mg/day)....

ea0035p12 | Adrenal cortex | ECE2014

New drugs switching off Wnt/β-catenin signaling in adrenocortical tumor cells

Rubin Beatrice , Pezzani Raffaele , Cicala Maria Verena , Iacobone Maurizio , Mantero Franco

Introduction: Adrenocortical tumors (ACT) are common diseases mostly benign, but among them, adrenocortical carcinomas (ACC) appear highly aggressive with metastatic potential. Wnt/β-catenin pathway is frequently switched on in ACT, with β-catenin greatly dephosphorylated and consequently activated. While IWR1 induces an increase in Axin2 protein levels, XAV939 inhibits tankyrase 1 and 2 (thus stabilizing Axin): both stimulate β-catenin phosphorylation and degra...

ea0020p8 | Adrenal | ECE2009

Effect of universal somatostatin analog (SOM230) on primary adrenal cell cultures

Mariniello Barbara , Finco Isabella , Rubin Beatrice , Patalano Anna , Ferasin Sergio , Iacobone Maurizio , Fassina Ambrogio , Mantero Franco

Introduction: Somatostatin (SST) is a widely distributed polypeptide that modulates the endocrine and exocrine secretion, cellular proliferation and differentiation, and apoptosis via G protein-linked receptors. Our previous studies showed high SSTR expression in adrenocortical carcinoma (ACC), aldosterone producing adenoma (APA) and in cortisol producing adenoma (CPA). Only very few information are available about the effectiveness of SST analogs in adrenal tumors.<p clas...

ea0016p19 | Adrenal | ECE2008

Angiogenic status of human adrenocortical tumors

Mariniello Barbara , Sartorato Paola , Finco Isabella , Patalano Anna , Iacobone Maurizio , Mantero Franco

Introduction: Angiogenesis plays a major role in cancer growth and metastasis. Differences in angiogenesis and the balance of angiogenic growth factors and inhibitors may play a role in determining the observed variations in tumor behaviour. VEGF overexpression in adrenocortical carcinomas (AC) has been recently shown. Moreover a new steroidogenic specific tissue angiogenic factor (EG-VEGF) has been described, and its role is presently unknown in adrenal tumors. Previous evide...

ea0016p48 | Adrenal | ECE2008

Persistent increase of osteoprotegerin levels after cortisol normalization in patients with Cushing's syndrome

Sanguin Francesca , Camozzi Valentina , Albiger Nora , Scaroni Carla , Mantero Franco , Luisetto Giovanni

Osteoprotegerin (OPG) has been identified as a decoy receptor that inhibits osteoclast differentiation and recently as a paracrine regulator of vascular calcification. OPG is suppressed by glucocorticoid administration. In this study, we evaluated OPG and bone metabolism in Cushing’s syndrome (CS) before and after surgical treatment. Twenty-nine patients with CS (26 women and 3 men, mean age: 40.7–2.8 years) and 27 age and sex-matched controls have been studied for b...

ea0016p421 | Neuroendocrinology | ECE2008

Glucose-dependent insulinotropic polypeptide receptor (GIPR) in human pituitary adenomas

Occhi Gianluca , Losa Marco , Albiger Nora , Scanarini Massimo , Del Verme Jacopo , Mantero Franco , Scaroni Carla

Glucose-dependent insulinotropic polypeptide (GIP) receptor is a member of the G protein-coupled receptors family. According to its incretin properties, GIPR is expressed in tissues such as pancreas, stomach and adipose tissue. However GIPR expression pattern appears to be broader, as it was detected in other tissues such as heart, lung and the central nervous system, thus suggesting either novel ligands for GIPR or novel actions for GIP. Moreover, in some patients with food-d...

ea0014p72 | (1) | ECE2007

Polymorphisms of von Willebrand factor gene promoter modulate the corticosteroid-mediated increase of VWF levels in Cushing’s syndrome.

Daidone Viviana , Sartorello Francesca , Albiger Nora , Mantero Franco , Pagnan Antonio , Casonato Alessandra , Scaroni Carla

Cushing’s syndrome (CS) is associated with hypercoagulable state, mainly dependent on corticosteroid-induced increase of von Willebrand factor (VWF) levels, even though this does not affects all patients. In normals plasma VWF levels are genetically determined by ABO blood groups and polymorphisms G/C −1793, C/T −1234, A/G −1185, G/A −1050 of VWF promoter. These SNPs segregate as haplotype 1 (G/C/A/G) and haplotype 2 (C/T/G/A) with genotype 1/1 (GG...

ea0014p155 | (1) | ECE2007

The effect of SOM230 on cell proliferation and cortisol secretion in the human adrenal carcinoma cell line H295R

Mariniello Barbara , Cervato Sara , Opocher Giuseppe , Albiger Nora , Occhi Gianluca , Scaroni Carla , Mantero Franco

Adrenocortical carcinoma (AC) is a rare neoplasm with poor prognosis. Medical treatment of AC is actually based on the use of op’DDD (mitotane) with or without traditional chemotherapeutic agents. Only very few information are available about the effectiveness of somatostatin analogs in AC. In human adrenal gland the expression of all five somatostatin receptor (SSTR) subtypes was previously demonstrated. A differential expression was shown in adrenal adenomas and carcino...