Searchable abstracts of presentations at key conferences in endocrinology

ea0029s18.3 | Molecular mechanisms in autoimmune thyroid disease | ICEECE2012

Regulatory cells, Th17 lymphocytes, and dendritic cells in autoimmune thyroid disease

Marazuela M.

Human autoimmune thyroid diseases (AITD), mainly including Hashimoto’s thyroiditis (HT) and Graves’ disease (GD), are characterized by reactivity to self-thyroid antigens. Regulatory T cells have an important role in immune tolerance to self-antigens. We have reported that different regulatory T cell subsets are abundant in the peripheral blood and in inflamed thyroid tissue in AITD and are able to synthesize the immunoregulatory cytokines IL-10 and TGF-beta. However...

ea0029p1488 | Pituitary Clinical | ICEECE2012

Pegvisomant and cabergoline combination therapy in acromegaly

Bernabeu I , Alvarez-Escola C , Paniagua A , Lucas T , Pavon I , Cabezas Agricola J , Casanueva F , Marazuela M

Objective: Combination with cabergoline may offer additional benefits to acromegalic patients on pegvisomant monotherapy. We evaluated the safety and efficacy profile of this combination and investigated the determinants of response.Design: An observational, retrospective, cross-sectional, registry-based study.Patients and methods: Fourteen acromegalic patients (9 females), who were partially resistant to somatostatin analogs and o...

ea0070aep327 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Metabolic effects of semaglutide after the first months of treatment: A new GLP-1-RA revolution?

Jiménez Sara , Pla Begoña , M Ramos-Leví Ana , Carraro Raffaele , Lahera Marcos , Hernando Iñigo , Alfonso Arranz J , Marazuela Mónica

Background: Semaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1-RA) whose role as a second-line treatment for patients with type 2 diabetes (T2D) has significantly increased. It has demonstrated cardiovascular safety and superiority in terms of glycaemic control and weight loss, compared to other GLP-1-RAs. The most common side effects are mild gastrointestinal, but it may also cause renal failure secondary to dehydration and an increased risk of diabetic retinopa...

ea0070aep488 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Evaluation of the results obtained with flash continuous glucose monitoring in patients with type 1 diabetes after a structured training program

Pla Peris Begoña , Ramos Leví Ana M , Lahera Vargas Marcos , Carraro Casieri Raffaele , Aguirre Moreno Nerea , Knott Torcal Carolina , Marazuela Mónica , Arranz Martín Alfonso

Introduction: Funding of continuous glucose monitoring (CGM) has been established by Madrid Health Service for adults with type1 Diabetes Mellitus (DM) who meet specific criteria. This has brought to lightthe need foran increasedinvestment in care time. In our Division, a structured training program has been established, consisting of 2 training sessions (TS); the first one based on basic contents to initiateFlash-CGM, and the second one, more intensive and targeted, focused o...

ea0070aep103 | Adrenal and Cardiovascular Endocrinology | ECE2020

Evaluation of clinical and functional differences between unilateral and bilateral adrenal incidentalomas. A spanish multicentric study.

Araujo Castro Marta , Robles Lázaro Cristina , Parra Ramírez Paola , García Centeno Rogelio , Gracia Gimeno Paola , Tome Mariana , Antonio Sampedro Núñez Miguel , Marazuela Mónica , Escobar-Morreale Héctor F , Valderrábano Herrero Pablo

Purpose: To evaluate differences in the prevalence of autonomous cortisol secretion (ACS) and related comorbidities between patients with unilateral and bilateral adrenal incidentalomas (AI).Methods: Seven Spanish institutions participated in this institutional review board-approved retrospective study for patients with AI. 342 patients with one or more AI ≥ 1 cm evaluated by participating physicians between 2001 and 2019 were subject to inclusion....

ea0014p127 | (1) | ECE2007

Effectiveness of retinoic acid treatment for redifferentiation of thyroid cancer in relation to recovery of radioiodine uptake

Fernández Fernández Cristián A. , Puig-Domingo Manel , Lomeña Francisco , Estorch Montserrat , Bittini Angel L , Marazuela Mónica , Santamaría Javier , Martín Tomás , Martínez de Icaya Purificación , Moraga Immaculada , Cuesta María , Mejías Ana , Porta Manel , Mauricio Dídac , Halperin Irene

Retinoic acid (RA) treatment has been used in the last decade for redifferentiation of metastatic thyroid cancer that have lost radioiodine uptake (RIup) with heterogeneous results.Aim: To evaluate the improvement of RIup after a course of RA treatment.Method: Retrospective analysis of 29 patients with radioiodine negative metastatic disease (17 men /12 women; 22 papillary, 4 follicular and 3 oncocytic tumours). RA was given at a d...

ea0073oc1.1 | Oral Communications 1: Adrenal and Cardiovascular Endocrinology | ECE2021

Risk of developing autonomous cortisol secretion and/or significant tumor growth in non-functioning adrenal incidentalomas during follow-up

Araujo Castro Marta , Lázaro Cristina Robles , Ramírez Paola Parra , García Centeno Rogelio , Gracia Gimeno Paola , Tome Mariana , Antonio Sampedro Núñez Miguel , Marazuela Mónica , Escobar-Morreale Héctor F. , Valderrábano Herrero Pablo

PurposeTo assess the risk of developing hypercortisolism and/or tumor growth in non-functioning adrenal incidentalomas (NFAIs) during follow-up.MethodsSeven Spanish institutions participated in this retrospective study for patients with AIs. 1097 patients with one or more AIs ≥ 1 cm evaluated by participating physicians between 2013 and 2020 were subject to inclusion. Patients with missing values in the...