Searchable abstracts of presentations at key conferences in endocrinology

ea0020p585 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Genetic alterations of phosphodiesterase 11A (PDE11A) in acromegalic patients

Peverelli Erika , Ermetici Federica , Filopanti Marcello , Lania Andrea , Ferrero Stefano , Beck-Peccoz Paolo , Spada Anna

Background: Aberrant cAMP signalling is involved in the pathogenesis of somatotropinomas. Recently, variants of phosphodiesterase type 11A (PDE11A) gene have been described in patients with adrenocortical tumors. Aim of the study was to investigate the presence of these variants in patients with somatotropinomas.Subjects and methods: Germ-line DNA of 78 acromegalic patients was screened for known genetic variants of PDE11A by direct sequencing or restric...

ea0014oc4.4 | Neuroendocriology basis | ECE2007

Is there a role for dopamine D2 receptor gene polymorphisms in determining cabergoline sensitivity in prolactin-secreting pituitary adenomas?

Filopanti Marcello , Barbieri Anna Maria , Angioni Rita , Lania Andrea , Mantovani Giovanna , Spada Anna , Beck-Peccoz Paolo

Dopamine agonist cabergoline (CB) is the first-choice treatment in prolactin-secreting adenomas (PRL-omas). It is effective in reducing PRL secretion and tumour size in about 90% of patients by binding dopamine D2 receptor (DRD2). Although no mutations in DRD2 were found, it has been reported that several polymorphisms of this locus associate with alcoholism and schizophrenia, diseases in which dopaminergic system plays an important role. To assess the possible asso...

ea0037gp.10.09 | Calcium, Vitamin D and Bone | ECE2015

Serum cystatin C levels were correlated with cardiometabolic features and cardiovascular diseases in patients with primary hyperparathyroidism

Verdelli Chiara , Ermetici Federica , Filopanti Marcello , Verga Uberta , Passeri Elena , Dito Giorgia , Malavazos Alexis Elias , Mapelli C , Raggi M E , Corbetta Sabrina

Patients with primary hyperparathyroidism (PHPT) are at risk of chronic kidney disease (CKD). PHPT patients (n=190, 146 females and 44 males, aged 59.7±14.2 years) and non-hypertensive, non-diabetic age- and sex-matched healthy controls were evaluated for serum cystatin C and creatinine. PHPT patients and controls with established CKD were excluded. Serum cystatin C was measured by immunonephelometric assay and calculation of estimated glomerular filtration rate ...

ea0037gp.19.02 | Pituitary–Acromegaly | ECE2015

Assessment of bone quality, measured by trabecular bone score, in acromegaly

Malchiodi Elena , Sala Elisa , Verrua Elisa , Cairoli Elisa , Carosi Giulia , Ferrante Emanuele , Filopanti Marcello , Ulivieri Fabio Massimo , Eller-Vainicher Cristina , Chiodini Iacopo , Mantovani Giovanna , Spada Anna

Introduction: Acromegaly is characterised by chronic exposure to high GH and IGF1 levels that leads to increased bone turnover. Regardless of BMD value, acromegalic patients seem to have an increased vertebral fracture risk probably due to a reduction of bone quality. Trabecular bone score (TBS) is a new index used for assessing bone microarchitecture. In this study TBS was used for the first time to analyze bone quality in acromegaly.Methods: 16 new acr...

ea0032p861 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Incidentally discovered pituitary adenomas: single-center experience on 205 patients

Malchiodi Elena , Ferrante Emanuele , Mantovani Giovanna , Toini Alessandra , Sala Elisa , Verrua Elisa , Giavoli Claudia , Filopanti Marcello , Spada Anna , Beck-Peccoz Paolo

Introduction: Pituitary incidentalomas are lesions discovered on an imaging study performed for an unrelated reason. Their frequency varies among 0.2–38% and it is continuously increasing due to the development of neuroimaging techniques. The aim of the study is to investigate clinical and biochemical characteristics of 205 consecutive patients (70% female, mean age 53.6±18.2 years) with incidental pituitary adenoma (IPA) followed at our center from 1990 to present.<...

ea0032p876 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Metabolic impact of IGF(CA)19 gene polymorphism on the response to GH therapy in adult GH-deficient (GHD) patients

Giavoli Claudia , Profka Eriselda , Sala Elisa , Filopanti Marcello , Bergamaschi Silvia , Ferrante Emanuele , Arosio Maura , Ambrosi Bruno , Spada Anna , Beck-Peccoz Paolo

Generously supported by IPSEN)-->A highly polymorphic microsatellite in the IGF-I gene promoter composed of variable cytosine–adenine (CA) repeats (n=10–24) has been linked to IGF-I levels, risk of diabetes and cardiovascular diseases with conflicting results. Aim of this study was to investigate the impact of this polymorphism on the response to rhGH (mean dose 0.34±0.14 mg/day) in adult GH-deficient (GHD) pa...

ea0032p878 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Role of IGF(CA)19 gene polymorphism in the clinical presentation of acromegaly

Sala Elisa , Mantovani Giovanna , Ferrante Emanuele , Barbieri Anna Maria , Malchiodi Elena , Verrua Elisa , Giavoli Claudia , Filopanti Marcello , Beck-Peccoz Paolo , Spada Anna

Introduction: A highly polymorphic microsatellite, comprising a variable length of a cytosine–adenosine (CA) repeat sequence, has been identified in the promoter region of IGF-I gene. The number of CA repeats ranges between 10 and 24 and the most common allele in the Caucasian population contains 19 CA (192 bp) repeats. Several studies investigated the relationship between this polymorphism and IGF-I levels, with conflicting results. Aim of this study was to investigate t...

ea0020p587 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

GH response to oral glucose tolerance test: a comparison between patients with pituitary disease and healthy subjects

Verrua Elisa , Ronchi Cristina Lucia , Ferrari Daniela Ilaria , Olgiati Luca , Ferrante Emanuele , Filopanti Marcello , Lania Andrea Gerardo , Beck-Peccoz Paolo , Spada Anna

Background: GH response to oral glucose tolerance test (OGTT) is currently used for the definition of disease remission in acromegaly. This test has been poorly investigated in other pituitary diseases.Aim: To evaluate the impact of a pituitary disease other than acromegaly on GH response to OGTT.Patients and methods: Eighteen patients (13 F & 5 M, age: 50.7±13.1 years) with different pituitary diseases (i.e. non-functioni...

ea0016p461 | Neuroendocrinology | ECE2008

d3-growth hormone receptor polymorphism (d3-GHR) is associated with low BMI and better glucose metabolism in acromegaly

Arosio Maura , Filopanti Marcello , Montefusco Laura , Olgiati Luca , Lucia Ronchi Cristina , Losa Marco , La Porta Carmen , Coletti Francesca , Lania Andrea , Beck-Peccoz Paolo , Spada Anna

Background: The d3-growth hormone receptor (GHR) polymorphism is a common variant characterized by genomic deletion of exon 3 (d3) of the GHR gene. It could be linked to a better growth response to GH, but the findings are controversial. Due to the lack of IGF-I feedback on the tumoral GH secretion, acromegaly seems to be a good model to study functional characteristics of this polymorphism. Aim of the study was to investigate possible influences of d3-GHR on GH and IGF-I rela...

ea0032p74 | Bone and Osteoporosis | ECE2013

Bone quality, as measured by trabecular bone score (TBS), in patients with primary hyperparathyroidism

Eller-Vainicher Cristina , Filopanti Marcello , Palmieri Serena , Ulivieri Fabio Massimo , Morelli Valentina , Zhukouskaya Volha V. , Cairoli Elisa , Pino Rosa , Naccarato Antonella , Verga Uberta , Scillitani Alfredo , Beck-Peccoz Paolo , Chiodini Iacopo

The fracture risk in primary hyperparathyroidism (PHPT) is partially independent of bone mineral density (BMD) and seems to depend on decreased bone quality, which is still reliably assessed only with invasive techniques. Trabecular bone score (TBS) is a grey-level texture measurement acquired during a dual X-ray absorptiometry (DXA) lumbar spine scan and it has been recently proposed as index of bone quality. This study is aimed to assess the role of TBS in predictin...