Searchable abstracts of presentations at key conferences in endocrinology

ea0020p186 | Endocrine tumours and neoplasia | ECE2009

mTOR inhibition influences cell viability of medullary thyroid carcinoma primary cultures

Filieri Carlo , Minoia Mariella , Tagliati Federico , Mole Daniela , Buratto Mattia , Margutti Angelo , degli Uberti Ettore , Chiara Zatelli Maria

Effective medical therapy for persistent/recurrent medullary thyroid carcinoma (MTC) is not available, yet. Everolimus (RAD001) is a Rapamycin derivative, a potent mTOR pathway inhibitor. RAD001 has been employed in several clinical studies demonstrating antiproliferative and apoptotic effects in human tumors, both in vitro and in vivo, also in combination with somatostatin analogs. The aim of our study was to investigate the antiproliferative effects of RAD001 i...