Endocrine Abstracts

A personalized patient treatment regimen for endogenous Cushing’s syndrome (CS) should be developed by a specialized multidisciplinary team, taking patient values and preferences into consideration. Comorbidities, which may compromise patient health and QoL need to be addressed, in many cases concomitant with or even before CS-specific treatments to restore eucortisolemia. Treatment of endogenous CS is initially primarily surgical and aims at complete resection of the und...

Background: 38% of teens use social media more than once an hour and 16% use it almost constantly (Rideout, 2018). Even so, the connection between smartphone use and nutrition and eating disorders is understudied and merits further study. Therefore, this study aims to examine the associations between smartphone use and eating disorders among adolescents.Methods: The study enrolled 325 participants aged 14-19 years in Florida, US, with 46% (n=150...

Microbiota plays a major role in health and disease in humans. Sex hormones influence the diversity and composition of the gut microbiota. Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in women of reproductive age (6–20%). PCOS is characterized by the association of androgen excess with oligomenorrhea, anovulatory infertility, and increased metabolic risk factors. The study of the interaction between gut microbiota and sex hormones in PCOS coul...

Even though serine-threonine kinase PAK1 is activated by estrogen and plays an important role in breast cancer, the role of PAK1 in estrogen response is not fully understood. We have shown that estrogen activates PAK1 through both ERα and GPER1 plasma membrane receptors and that cytoplasmic Etk/Bmx directly phosphorylates Tyr153-PAK1 and activates PAK1 in response to estrogen. We have described a signaling complex composed of pTyr-PAK1, Etk, the heterotrimeric G-protein s...

Introduction: Pregnancy in patients with acromegaly is a rare and challenging medical situation. Here in, we report a patient with acromegaly who presented to us in the 3rdtrimester of pregnancy after endoscopic transnasaltranssphenoidal radical excision of the tumor.Observation: A 36-year-old lady (Gravida 3 Parity 2 Live Birth 2), presented to our outpatient clinic on May 2007 forsuspicion of acromegaly. Clinical examination revealed acromeg...

The majority of differentiated thyroid cancer (DTC) cases will be successfully treated with surgery usually (but not always) followed by radioiodine (RAI). The large majority have excellent prognosis. 10% of DTC may present disease progression: local relapse and/or distant metastases. 25–50% of these will slowly loose the capacity to take up radioiodine – RAI refractory cases. Further management includes loco-regional therapies such as surgical excision of lesions ca...

GS, Patients have hypokalemia, metabolic alkalosis, hypomagnesemia, and hypocalciuria together with normal blood pressure. Most of the patients are clinically asymptomatic, but some patients experience seizures, muscle weakness, cramps, episodic tetany, and paresthesia. The diagnosis is usually made based on clinical features and laboratory blood test. In this study we present a young patient with persistent hypokalaemia. She feels well in herself. She denies any symptoms of h...

Thyroid cancer (DTC) is diagnosed more frequently these days due to increased awareness, wider availability of detection tools and, possibly, to true increasing incidence. The epidemiology of DTC is thus changing and more ‘innocent’ tumours are now being detected. The management of thyroid cancer and nodules is evolving and much progress has recently been made in the diagnosis and follow-up. Management guidelines have recently been published by scientific bodies and ...

A 16-year-old boy presented in September 2007 with headaches and droopy eye lid due to pituitary mass. His initial prolactin level was 320 832 mu/l which confirmed the diagnosis of macroprolactinoma.His glucagon test revealed him to be growth hormone deficient with normal thyroid function test and testosterone on the lower end of normal. He was then treated with cabergoline 0.5 mg once a week and growth hormone injection 0.8 mg once a day. In June 2008, his prolactin levels we...

BackgroundGrowth hormone replacement therapy in adults is mostly used in case of adult growth hormone deficiency (AGHD). The condition is characterized by altered body composition, lower than average bone mineral density (BMD), elevated cardiovascular risks and, among other remaining factors, lower quality of life.Main discussion topicsAfter over 30 years of recombinant growth hormone (rGH) usage substantial ...