Searchable abstracts of presentations at key conferences in endocrinology

ea0081p479 | Thyroid | ECE2022

Role of irisin as modulator of antioxidants in two models of non-thyroidal illness syndrome

Bruno Carmine , Vergani Edoardo , Capobianco Emmanuele , Anna Nicolazzi Maria , Maria Rita Favuzzi Angela , Silvestrini Andrea , Meucci Elisabeta , Panocchia Nicola , Mancini Antonio

Non-thyroidal-illness syndrome (NTIS) is present in chronic diseases and considered an adaptive mechanism. However oxidative stress is linked to NTIS in a vicious circle, due to deiodinases alteration and negative effects of low T3 on antioxidant levels or activity. Moreover there is a tissue-specific thyroid hormone transport, receptor binding and hormone metabolism. Muscle is one of the main targets of thyroid hormone; on the other hand, Irisin is a novel discovered myokine ...

ea0070aep15 | Adrenal and Cardiovascular Endocrinology | ECE2020

Multiple hormonal deficiency in heart failure with preserved ejection fraction: Prevalence and role in modulation of antioxidant levels and myocardial dysfunction indexes

Bruno Carmine , Vergani Edoardo , Calarco Rodolfo , Anna Nicolazzi Maria , Maria Rita Favuzzi Angela , d’Abate Claudia , Silvestrini Andrea , Meucci Elisabetta , Mordente Alvaro , Mancini Antonio

In heart failure with reduced ejection fraction, catabolic mechanisms have a strong negative impact on mortality and morbidity. The relationship between anabolic hormonal deficiency and heart failure with preserved ejection fraction (HFpEF) has still been poorly investigated. On the other hand, oxidative stress is recognized as a player in the pathogenesis of HFpEF. Therefore, we performed a cohort study in HFpEF in order to: 1) define the multi-hormonal deficiency prevalence ...