Searchable abstracts of presentations at key conferences in endocrinology

ea0016s14.6 | Basic highlights | ECE2008

Specific neuronal deletion of cannabinoid type 1 receptor (CB1) mice exhibits reduced fat mass and diet-induced obesity resistance

Cervino Cristina , Bellocchio Luigi , Quarta Carmelo , Mariani Corea Vania A , Mancini Giacomo , Vicennati Valentina , Lutz Beat , Marsicano Giovanni , Pasquali Renato , Pagotto Uberto

Aims: Recently, the endocannabinoid system emerged as a pivotal regulator of food intake, ingestive behavior and energy metabolism, acting through CB1 and its endogenous ligands, the endocannabinoids. CB1 antagonists may reduce body weight and improve metabolic profiles in animals and humans by a double mechanism: at first, they target mesolimbic and hypothalamic nuclei and, thereafter, peripheral organs involved in energy storage and expenditure. Nevertheless, it is still unk...