Searchable abstracts of presentations at key conferences in endocrinology

ea0020oc6.4 | Paediatric Endocrinology/Bone | ECE2009

Appearance matters: the impact of perceived altered appearance as a result of Klinefelter's syndrome on psycho-social functioning

Jackson Sue , Morris Marianne

Background: Klinefelter’s syndrome (KS) is a genetic condition affecting men with the potential to severely reduce their testosterone levels and affect their physical appearance. Being a syndrome there are a variety of different symptoms which individuals may experience to a great or lesser extent. While much research has been directed at understanding the cognitive impact of KS much less research has been undertaken considering the psycho-social impact of living with the...

ea0020p563 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

The impact of infertility on the relationship of people with a Pituitary condition

Morris Marianne , Harrison Pascale

Background: Evidence from a Needs Analysis (2006) and Patient Satisfaction Survey (2008) for people with pituitary conditions, suggested infertility was a key yet unexpected problem for the majority of respondents. Being infertile without the co-morbidity of having a pituitary condition confers a huge emotional burden on the couple concerned. The aim of this study was to explore in detail the effects infertility imposed on people with a pituitary condition.<p class="abstex...

ea0041ep22 | Adrenal cortex (to include Cushing's) | ECE2016

Method-specific serum cortisol responses to the ACTH test: comparison of two generations of Roche automated immunoassays using polyclonal vs MABs

Klose Marianne , Hilsted Linda , Feldt-Rasmussen Ulla

Introduction: The plasma cortisol response to the ACTH test is known to vary significantly by assays. An automated cortisol immunoassays with increased specificity due to the shift from polyclonal to MABs, and standardized against mass spectrometry was recently introduced, with an expected decrease in cortisol concentrations by 20%. Cut-offs used in clinical practice for patient evaluation will thus have to be adjusted. We aimed to assess the normal cortisol response to ACTH s...

ea0070aep835 | Reproductive and Developmental Endocrinology | ECE2020

Autoimmune characteristics in women with addisons disease and primary ovarian insufficiency

Vogt Elinor , Øksnes Marianne , Husebye Eysetein

Background: In women with autoimmune primary adrenal failure (AD) there is a high prevalence of autoimmune primary ovarian failure (POI). Whether the oophoritis is caused by an unknown ovary-specific autoantibodyor cross-autoimmunity with steroid hormone producing cells in the adrenal cortex is unknown. Autoimmune POI can also affect women without AD. Autoantibodies against steroidogenic enzymes are useful diagnostic markers in AD but are of uncertain value in idiopathic POI.<...

ea0028p138 | Growth and development | SFEBES2012

More information, please! Results of a survey on men with Klinefelter’s syndrome and their satisfaction with information and support from healthcare professionals

Jackson Sue , Morris Marianne , Ruddle Georgina

Introduction: Klinefelter’s Syndrome (KS) is a genetic condition affecting men with the potential to severely reduce testosterone levels and affect physical appearance. Being a syndrome there are a variety of different symptoms which individuals may experience to a great or lesser extent. With no screening programme in place, KS may not be detected until puberty, or until men have problems starting a family. As a result, many different healthcare professionals (HCPs) are ...

ea0020p425 | Diabetes and Cardiovascular | ECE2009

Effects of oral contraceptives versus no treatment on glucose tolerance and patients’ satisfaction during long time follow up in 69 hirsute patients

Andries Magdalene , Glintborg Dorte , Andersen Marianne

Objective: To evaluate the long term risk for diabetes and insulin resistance in untreated and oral contraceptive (OC) treated hirsute patients.Design: Cross sectional study.Setting: Academic tertiary-care medical centre.Patients: Of 233 Caucasian hirsute women were evaluated during 1997–2002 (baseline) and re-contacted in 2003–2004. Of 159 patients returned questionnaires and 69 attended clinical e...

ea0032p877 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Hypopituitarism after fractionated stereotactic radiation therapy of anterior skull base meningiomas is caused by mass effects, not radiation

Moeller Emil , Astradsson Arnar , Klose Marianne , Roed Henrik , Feldt-Rasmussen Ulla , Juhler Marianne

Introduction: Fractionated stereotactic radiotherapy (FSRT) is used in the treatment of surgically inaccessible meningiomas, primarily in the base of the skull. Development of hypopituitarism following FSRT is inexhaustively investigated. We aimed to elucidate the cause of hypopituitarism in patients treated with FSRT for benign meningiomas of the anterior skull base.Methods: All patients undergoing FSRT for benign meningioma of the skull base between Ju...

ea0081p311 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Oxidative stress decreased after six months testosterone treatment compared to placebo in ageing men – a randomized, double-blind trial

Christensen Louise Lehmann , Andersen Marianne , Enghusen Poulsen Henrik , Glintborg Dorte

Background: High oxidative stress is associated with increased morbidity. The effect of testosterone treatment (TT) on oxidative stress in ageing men with reduced bioavailable testosterone is undetermined.Aim: To determine the effect of TT compared to placebo on oxidative stress biomarkers.Methods: Double-blinded, placebo-controlled study in 38 men, aged 60–78 years, with bioavailable testosterone <7.3 nmol/l and waist cir...

ea0090p292 | Adrenal and Cardiovascular Endocrinology | ECE2023

Significance of exogenous estradiol on plasma cortisol during ACTH stimulation in women with pituitary insufficiency

Aagaard Laura , Krogh Jesper , Klose Marianne , Andreassen Mikkel

Objective: Exogenous estradiol increases cortisol binding globulin (CBG) and total cortisol (TC), and therefore it is debated if estradiol supplementation should be paused before evaluation of the adrenal axis. The aim was to evaluate how oral and transdermal estradiol influence TC in hypogonadal women with, or at risk of developing, adrenal insufficiency (AI)Methods: This was a crossover study in 17 women with secondary hypogonadism who were tested with...