Searchable abstracts of presentations at key conferences in endocrinology

ea0021p151 | Diabetes and metabolism | SFEBES2009

Effect of rimonabant and metformin on oxidative stress in obese patients with polycystic ovary syndrome (PCOS)

Aye Myint M , Shepherd John , Cho Liwei , Ng J M , Marie Coady Anne , Kilpatrick Eric S , Atkin Stephen L , Sathyapalan Thozhukat

Background: Insulin resistance and obesity are characteristic features of PCOS. Oxidative stress leads to the formation of lipid peroxidation products in the skeletal muscles and has the potential to interfere with insulin signaling and thereby contribute to insulin resistance. Malondialdehyde (MDA) is a lipid peroxidation end product and is widely used as a marker of oxidative stress.Rimonabant has been shown to reduce weight and insulin resistance in o...