Searchable abstracts of presentations at key conferences in endocrinology

ea0081p36 | Calcium and Bone | ECE2022

Denosumab vs. zoledronic acid treatment in post-menopausal breast cancer: a 2-year prospective observational study

Buch-Larsen Kristian , Marina Djordje , Schwarz Peter

Adjuvant treatment for post-menopausal women with early breast cancer (BC) includes aromatase inhibitors (AI), known to decrease bone mineral density (BMD). In this study, we investigate whether denosumab is a valid second option for patients unable to receive standard adjuvant i.v. zoledronic acid (ZA). In total, 212 patients have been evaluated after they did not receive ZA. Of those 194 were included. After evaluation by an endocrinologist, all patients were offered ZA as t...

ea0020p11 | Adrenal | ECE2009

Are there some alterations of salivary cortisol dynamics in obese patients?

Jelic Svetlana , Caparevic Zorica , Ilic Sanja , Marina Djordje

The metabolic syndrome resembles Cushing’s syndrome in several clinical aspects. Main characteristic of both syndromes is obesity assessed by the body mass index (BMI) or waist circumference (WC).The aim of this study was to investigate cortisol dynamics in 20 healthy volunteers (BMI<27 kg/m2; 13 females, 7 males, age 42.1+12.39 years) and 20 obese patients (BMI≥27 kg/m2; 13 females, 7 males, age 49.25+1...

ea0032p879 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Relationship between early endocrine alterations and functional outcome in patients with severe brain injury

Marina Djordje , Klose Marianne , Nordenbo Annette , Liebach Annette , Westergaard Lars , Feldt-Rasmussen Ulla

Introduction: Recently, it has been suggested that hypopituitarism developed after the brain injury has implications in the final recovery of the patients. We hypothesize that hypopituitarism developed in the course of traumatic brain injury (TBI) or non-TBI is related to worse functional outcome. The aim was to assess the association between hypopituitarism in the early recovery phase and long-term functional outcome.Materials and methods: We included 1...

ea0020p381 | Diabetes and Cardiovascular | ECE2009

Plasminogen activator inhibitor 1 and atherosclerosis in diabetes mellitus type 2

Ilic Sanja , Kostic Nada , Caparevic Zorica , Radojkovic Jana , Jelic Svetlana , Marina Djordje

Background and aims: Plasminogen activator inhibitor -1 (PAI-1) increases in diabetes and this might contribute to decreased fibrinolisis and accelerated atherosclerosis. PAI-1 is also contributor to the development of acute myocardial infarction. Measurement of intimal medial thickening (IMT) is indicator of presence and extent of coronary artery disease. Aim of the study was to find association between PAI-1 marker of decreased fibrinolisis and atherosclerosis by measuring I...

ea0020p605 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Hypothalamic–pituitary–adrenal axis in chronic fatigue syndrome

Marina Djordje , Jelic Svetlana , Kostic Nada , Caparevic Zorica , Trbojevic Bozo , Beleslin Biljana , Ilic Sanja , Zarkovic Milos

Background/objectives: The aim of the study was to assess hypothalamic–pituitary–adrenal (HPA) axis in patients with chronic fatigue syndrome (CFS).Design and methods: Twenty-three consecutive patients who fulfilled centers for disease control (CDC) criteria for CFS and twenty healthy controls were included in the study. Low dose ACTH test (1mcg of synthetic adrenocorticotropic hormone Synacthen) and insulin tolerance test (ITT) were done and b...

ea0016p24 | Adrenal | ECE2008

Association of diabetes mellitus and arterial hypertension in adrenal incidentaloma

Zarkovic Milos , Ciric Jasmina , Beleslin Biljana , Savic Slavica , Stojkovic Mirjana , Marina Djordje , Trbojevic Bozo

Background/objectives: The aim of the study was to assess association between diabetes mellitus (DM) and arterial hypertension (AH) in patients with adrenal incidentaloma.Design and methods: One hundred and eleven consecutive patients with incidentally discovered adrenal tumours were included in the study. OGTT was done and 24 h urinary catecholamines were measured. Aldosterone and plasma renine activity (PRA) were determined, and 1 mg dexametasone test ...

ea0016p619 | Reproduction | ECE2008

Intima-media tickness of carotid artery in young women with polycystic ovary syndrome

Stojkovic Mirjana , Civcic Milorad , Beleslin Biljana , Ciric Jasmina , Savic Slavica , Marina Djordje , Trbojevic Bozo , Zarkovic Milos

Background: Polycystic ovary syndrome (PCOS) is a common endocrine-metabolic disease that occurs in about 10% of women in reproductive age. Today, PCOS is considered not only reproductive edocrinopathy but also a metabolic disorder associated with long-term health risks, including diabetes mellitus and cardiovascular disease.Objectives: The aim of this study was to evaluate the presense of early vascular demage in normal-weight women with polycystic ovar...

ea0016p732 | Thyroid | ECE2008

Correlations between lipids and thyroid hormones in primary hypothyroidism

Savic Slavica , Trbojevic Bozo , Ciric Jasmina , Beleslin Biljana , Marina Djordje , Stojkovic Mirjana , Zarkovic Milos

The aim of the study was to assess the influence of thyroid hormones on lipid profiles in primary hypothyroidism, in order to determine the most influential one for the clinical follow-up. Study group included 15 subjects (3 male, 12 female, age 46±13 years/mean±S.D.), and total and free T4, total and free T3 and TSH, total, HDL and LDL cholesterol, triglycerides, ApoA, ApoB and Lp(a) were determined. The diagnosis of primary hypothyroidism was based o...

ea0014p649 | (1) | ECE2007

Insulin levels and lipid profile in lean women with polycystic ovary syndrome

Stojkovic Mirjana , Zarkovic Milos , Ciric Jasmina , Beleslin Biljana , Savic Slavica , Marina Djordje , Trbojevic Bozo , Drezgic Milka

Background: Women with polycystic ovary syndrome (PCOS) appear at increased cardiovascular risk due in part to a dyslipidemia characterized by increased plasma triglyceride and reduced high density lipoprotein (HDL) cholesterol levels. Insulin resistance is one of the features of PCOS and potentially affect lipid metabolism.Objectives: The aim of this study was to compare basal insulin levels and lipid profile in lean women with PCOS with weight matched ...