Searchable abstracts of presentations at key conferences in endocrinology

ea0099p563 | Reproductive and Developmental Endocrinology | ECE2024

Investigation of circulating androgens’ circadian variations: expanding the knowledge by monitoring phase II metabolites

Ponzetto Federico , Parasiliti Caprino Mirko , Campioni Lorenzo , Marinelli Lorenzo , Settanni Fabio , Nonnato Antonello , Mengozzi Giulio , Giordano Roberta , Ghigo Ezio

Background: Many endogenous steroid hormones are reported to be subjected to distinct circadian rhythms, which are driven by central regulators, hormonal bioavailability and half-life. Recently, the measurement of androgens phase II metabolites has gained interest in the diagnosis and management of different endocrinological pathologies, such as polycystic ovarian syndrome (PCOS), female adrenal hyperandrogenism and hirsutism, prostate cancer, but their circadian patterns have...

ea0099ep571 | Reproductive and Developmental Endocrinology | ECE2024

Short and long-term efficacy of minoxidil on beard growth in a group of assigned female at birth transgender people on gender affirming hormone therapy

Marinelli Lorenzo , Bichiri Andreina , Ghigo Ezio , Motta Giovanna

Introduction: Minoxidil is a vasodilator drug used as topical treatment of androgenetic alopecia; however, its efficacy for beard enhancement is reported in cisgender men and in a case-report of a transgender assigned female at birth (t-AFAB) adolescent. This study aims to evaluate the short- and long-term efficacy of topical minoxidil in a group of t-AFAB people on gender affirming hormone therapy (GAHT) with testosterone.Materials and methods:...

ea0081oc12.6 | Oral Communications 12: Reproductive and Developmental Endocrinology | ECE2022

Analysis of cardiovascular comorbidities and events in a cohort of transgender people during GAHT

Marinelli Lorenzo , Camandona Andrea , Crespi Chiara Michela , Magistri Domiziana , Ghigo Ezio , Motta Giovanna

Introduction: According to the DSM-5, gender dysphoria (GD) is defined as a distress that results from an incongruence between one’s sex assigned at birth and one’s gender identity. This condition may require gender-affirming hormone therapy (GAHT), in order to reduce distress. GAHT, however, is not free from side effects and it could increase the risk of onset of new pathological conditions.Aim of the study: To evaluate cardiovascular comorbid...

ea0102100 | Reproductive Endocrinology | EYES2024

Short-term changes in bone metabolism among transgender men starting gender affirming hormone therapy: a systematic review and meta-analysis

Marinelli Lorenzo , Tienforti Daniele , Vervalcke Jeroen , Bichiri Andreina , T'Sjoen Guy , Motta Giovanna , Barbonetti Arcangelo

Introduction: Transgender and gender diverse (TGD) people experience a gender identity which is different from the sex assigned at birth. Some transgender men (TM) can ask for testosterone to induce virilization and its effects on bone health are still to be fully elucidated. The aim of this systematic review and meta-analysis was to evaluate the changes on bone metabolism in a short-term period among TM starting testosterone. Methods: A systematic searc...

ea0099p366 | Reproductive and Developmental Endocrinology | ECE2024

“Brief intelligence test” questionnaire in klinefelter syndrome: may words improve diagnosis?

Vimercati Davide , Marinelli Lorenzo , Cagnina Serena , Daffara Tommaso , Bichiri Andrea , Di Bisceglie Cataldo , Motta Giovanna , Lanfranco Fabio , Zavattaro Marco

Background: The clinical burden of Klinefelter Syndrome (KS) is not limited to the impairment of gonadal function and an increased prevalence of cardio-metabolic, endocrinological and oncological diseases, but also involve several cognitional, behavioural and psychological issues. Because of the wide heterogeneity in clinical phenotype, the diagnosis of KS is still challenging, resulting in a significant number of patients to remain undiagnosed or to have a late diagnosis. Ver...

ea0090oc4.1 | Oral Communications 4: Reproductive and Developmental Endocrinology | ECE2023

Gender-affirming hormone treatment: friend or foe? Long term follow-up of 755 transgender and gender diverse people

Spaggiari Giorgia , Marinelli Lorenzo , Cacciani Marta , Scipio Sofia , Bichiri Andreina , Profeta Alessandra , Granata Antonio Raffaele Michele , Ghigo Ezio , Simoni Manuela , Motta Giovanna , Santi Daniele

Background: Gender-affirming hormone treatment (GAHT) is the cornerstone in the therapeutic management of transgender and gender diverse (TGD) people, which are currently classified as transgender assigned-female-at birth (t-AFAB) and assigned-male-at birth (t-AMAB) subjects. Due to its hormonal nature, GAHT is commonly handled by the endocrinologist and available guidelines on this topic mimic the recommendations for cis-gender hypogonadal populations. However, the GAHT long ...

ea0073oc10.6 | Oral Communications 10: Thyroid | ECE2021

Impact of allogeneic stem cell transplantation on thyroid function

Felicetti Francesco , Zavattaro Marco , Faraci Danilo , Gatti Filippo , Dellacasa Chiara , Busca Alessandro , Arvat Emanuela , Rosso Daniela , Marinelli Lorenzo , Margherita Dionisi-Vici , Giaccone Luisa , Bruno Benedetto , Brignardello Enrico

IntroductionPrimary hypothyroidism, which is one of the main endocrine complications of allogenic stem cells transplantation (allo-SCT), has been largely studied in children. Conversely, data on adults are still limited with a reported incidence widely ranging between 9 and 47%. Older age, multiple allo-SCT, chronic Graft vs Host Disease (cGVHD), prolonged immunosuppressive therapy and high-dose total body irradiation (TBI) have been indicated as potenti...