Searchable abstracts of presentations at key conferences in endocrinology

ea0020p8 | Adrenal | ECE2009

Effect of universal somatostatin analog (SOM230) on primary adrenal cell cultures

Mariniello Barbara , Finco Isabella , Rubin Beatrice , Patalano Anna , Ferasin Sergio , Iacobone Maurizio , Fassina Ambrogio , Mantero Franco

Introduction: Somatostatin (SST) is a widely distributed polypeptide that modulates the endocrine and exocrine secretion, cellular proliferation and differentiation, and apoptosis via G protein-linked receptors. Our previous studies showed high SSTR expression in adrenocortical carcinoma (ACC), aldosterone producing adenoma (APA) and in cortisol producing adenoma (CPA). Only very few information are available about the effectiveness of SST analogs in adrenal tumors.<p clas...

ea0016p19 | Adrenal | ECE2008

Angiogenic status of human adrenocortical tumors

Mariniello Barbara , Sartorato Paola , Finco Isabella , Patalano Anna , Iacobone Maurizio , Mantero Franco

Introduction: Angiogenesis plays a major role in cancer growth and metastasis. Differences in angiogenesis and the balance of angiogenic growth factors and inhibitors may play a role in determining the observed variations in tumor behaviour. VEGF overexpression in adrenocortical carcinomas (AC) has been recently shown. Moreover a new steroidogenic specific tissue angiogenic factor (EG-VEGF) has been described, and its role is presently unknown in adrenal tumors. Previous evide...

ea0014p155 | (1) | ECE2007

The effect of SOM230 on cell proliferation and cortisol secretion in the human adrenal carcinoma cell line H295R

Mariniello Barbara , Cervato Sara , Opocher Giuseppe , Albiger Nora , Occhi Gianluca , Scaroni Carla , Mantero Franco

Adrenocortical carcinoma (AC) is a rare neoplasm with poor prognosis. Medical treatment of AC is actually based on the use of opÂ’DDD (mitotane) with or without traditional chemotherapeutic agents. Only very few information are available about the effectiveness of somatostatin analogs in AC. In human adrenal gland the expression of all five somatostatin receptor (SSTR) subtypes was previously demonstrated. A differential expression was shown in adrenal adenomas and carcino...

ea0032p17 | Adrenal cortex | ECE2013

Role of adrenal vein sampling in primary aldosteronism: impact of different diagnostic criteria on subtype diagnosis

Cicala Maria-Verena , Salva Monica , Miotto Diego , Rubin Beatrice , Pezzani Raffaele , Patalano Anna , Iacobone Maurizio , Mariniello Barbara , Mantero Franco

In patients with primary aldosteronism (PA), adrenal vein sampling (AVS) is considered the gold standard to distinguish between unilateral and bilateral autonomous production of aldosterone, while diagnostic imaging tests by CT scan or MRI are often inconclusive for the diagnosis. To date agreement is lacking on the best criteria indicating successful cannulation and lateralization.The aim of the study was to evaluate the impact of different diagnostic c...