Searchable abstracts of presentations at key conferences in endocrinology

ea0099ep1191 | Pituitary and Neuroendocrinology | ECE2024

Challenges in treatment of cortikotroph pituitary macroadenoma

Dojcinovic Tamara , Markovic Aleksandra , Malinovic Pancic Jelena

Cushing’s syndrome is a condition characterized by hypercortisolism (endogenous and exogenous) regardless of its etiology. Hypercortisolism caused by an adrenocorticotropin secreting pituitary adenoma is defined as Cushing’s disease. These tumors represent 10-12% of all pituitary adenomas. ACTH-secreting macroadenomas occur in only 4-23% of all patients with Cushing’s disease. We present the case of 56-year-old female patient with hypercortisolism and stigmata o...

ea0049ep1184 | Neuroendocrinology | ECE2017

Prenatal testosterone exposure increases anxiety-like behavior in female rats

Rasic-Markovic Aleksandra , Macut Djuro , Hrncic Dragan , Cirkovic Valentina , Rankov-Petrovic Bojana , Sutulovic Nikola , Stanojlovic Olivera

Polycystic ovary syndrome (PCOS) is characterized by excessive androgen secretion and women with PCOS are at risk of developing anxiety disorders. Maternal testosterone levels in humans have been shown to affect brain development and to be correlated to mental function. During pregnancy, women with PCOS display high circulating androgen levels that may affect the fetus and increase the risk of mood disorders in offspring. This study investigated whether maternal androgen exces...

ea0099ep38 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024

Relations of C-reactive protein to post-glucose load glucose in patients with prediabetes and coronary artery disease

Tankovic Valentina , Stankovic Sinisa , Popovic Pejicic Snjezana , Malesevic Gabrijela , Markovic Aleksandra , P. Macut Djuro

Introduction: The association between CRP and prediabetes has not been sufficiently investigated. The aim of the study was to determine the association of prediabetes with subclinical inflammation, as well as to examine the correlation of sensitive CRP (hsCRP) with fasting glycemia and 2 h glycemia during exercise during the OGTT test.Methods: The study included 106 patients with angiographically diagnosed coronary artery disease, who, based on the oral ...

ea0099ep336 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024

Secondary failure of oral therapy in patients with type 2 diabetes mellitus - possibilities of overcoming

Markovic Aleksandra , Bojic Mirjana , Dojcinovic Tamara , Risovic Ivona , Brkic Milena , Soldat Stankovic Valentina , Macut Djuro

Introduction: Secondary failure (SF) of oral therapy in patients with type 2 diabetes is a common clinical phenomenon, which often puts the practitioner in a dilemma as to which therapeutic regimen to choose for continuing therapy. The dilemma primarily applies to patients in whom there is no clear clinical and biochemical evidence of significant insulin deficiency. This is precisely why there has been an increased interest in the use of short-term intermittent insulin therapy...

ea0099ep1195 | Pituitary and Neuroendocrinology | ECE2024

Therapeutic challenges in the treatment of acromegaly

Markovic Aleksandra , Bojic Mirjana , Dojcinovic Tamara , Djekic Danijel , Caric Bojana , Malinovic-Pancic Jelena

Introduction: Acromegaly is a chronic disease that occurs as a result of excessive growth hormone secretion, caused by somatotropin-secreting tumors of the pituitary gland in 98% of cases. The first line of treatment for these patients is operative via transsphenoidal approach, however, absolute remission is not achieved in 50% of patients and pharmacological therapy is indicated.Case report: We will present the case of a 43-year-old patient who was hosp...

ea0099ep437 | Reproductive and Developmental Endocrinology | ECE2024

PCOS-like syndrome in the young woman with cortisone reductase deficiency type 1

Krstic Katarina , Ognjanovic Sanja , Popovic Bojana , Ilic Dusan , Elezovic Kovacevic Valentina , Bjekić Macut Jelica , Opalic Palibrk Milica , Radic Lena , Stanojlović Olivera , Rasic Markovic Aleksandra , Vojnovic Milutinovic Danijela , Macut Djuro

Introduction: 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a dimeric enzyme that catalyzes the reduction of cortisone to cortisol within the endoplasmic reticulum. Loss of this activity results in a disorder termed cortisone reductase deficiency type 1 (CRD). Only mutations in H6PD gene, which encodes an enzyme supplying cofactor for the reaction, have been identified as the cause of disease. Biochemical features of CRD are increased cortisol clearance and A...