Searchable abstracts of presentations at key conferences in endocrinology

ea0086p158 | Adrenal and Cardiovascular | SFEBES2022

Salivary dexamethasone and 11-dehydrodexamethasone analysis post overnight dexamethasone suppression test

Marshall David , Keevil Brian , Issa Basil

Background: The 1 mg overnight dexamethasone suppression test (ONDST) is recommended as a first-line test for the investigation of Cushing Syndrome. Measurement of dexamethasone alongside cortisol in a 9am serum sample has been credited with improving diagnostic sensitivity of the test. Previous studies have also looked at the utility of salivary dexamethasone and have observed poor correlation with serum dexamethasone. Herein we introduce the concept of measuring 11-dehydrode...

ea0086p20 | Adrenal and Cardiovascular | SFEBES2022

Cortisol/cortisone measurement in sweat samples

Keevil Brian , Marshall David , Adaway Jo , Hawley James

Introduction: Alternative biofluids such as sweat, which can be obtained non-invasively and present a simpler matrix composition than serum/plasma or urine, may be useful for monitoring biomarkers. The long-term sampling with patches either on the chest or back can be conveniently used under both rest and exercise conditions to provide an integrated response of free biomarkers over the course of a day. The smaller sample volumes generated by sweat collection can be convenientl...

ea0015p293 | Reproduction | SFEBES2008

Desensitisation of oxytocin receptors with labour-onset in isolated human myometrium

Fischer Deborah , Farrar Diane , O'Donovan Peter , Woodward David , Marshall Kay

Although oxytocin is a potent stimulant of myometrial contractions, its role in parturition is controversial. The aim of the present study was to elucidate the functional mechanisms of oxytocin receptors in isolated human myometrium before and after labour-onset.Myometrial biopsies were obtained from consenting women (aged 21–34 years) undergoing Caesarean section at term pregnancy, not in labour (n=6), or in early (n=6) or late (n<...

ea0016p637 | Reproduction | ECE2008

Topographical effects of functional prostanoid and oxytocin receptors on mid-cycle contractions in isolated human myometrium

Fischer Deborah , O Donovan Peter , Farrar Diane , Woodward David , Marshall Kay

Dysfunctional prostanoid and oxytocin receptors have been implicated in the development of myometrial hyperactivity, causing dysmenorrhoea and infertility. The aim of the present study was to investigate the topographical differences in functional contractile PG and oxytocin receptors in mid-cycle isolated myometrium.Longitudinal, full-thickness sections of the anterior uterus were obtained from consenting pre-menopausal donors (aged 39–48 years) un...