ea0038oc1.1 | Early Career Oral Communications | SFEBES2015
George Jyothis
, Kakkar Rahul
, Marshall Jayne
, Scott Martin
, Finkelman Richard
, Ho Tony
, McIntosh Stuart
, Veldhuis Johannes
, Skorupskaite Karolina
, Anderson Richard
, Webber Lorraine
LH hyper-secretion, driven by increased GnRH pulsatility, underpins excess testosterone secretion a key clinical feature of PCOS.The kisspeptin-neurokinin B (NKB)-GnRH pathway has emerged as the pivotal regulator of reproduction. We hypothesised that pharmacologic blockade of NKB may address the central pathophysiology of LH hyper-secretion and hyperandrogenism in PCOS. We undertook a randomised, double blind, placebo-controlled multi-centre Phase...