Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep894 | Thyroid | ECE2020

Association between multifocality and aggressive histopathological findings in papillary thyroid cancer

Monzón Mendiolea Andoni , Oleaga Alday Amelia , Leyre Martínez Martínez Adela , Merlo Pascual Ignacio , Etxeberria Martin Eider , Paja Fano Miguel

Introduction: Papillary thyroid cancer (PTC) is usually tied to an excellent prognosis, with a 10-year disease specific survival rate of 98%. Nevertheless, some clinicopathological features are associated with a worse outcome. Therefore, a precise risk assessment is crucial for the clinicians deciding the most appropriate treatment for each tumour. Multifocal tumours (MFPTC) appear to have be a worse prognosis than unifocal tumours (UFPTC) in some series, but this aspect is di...

ea0073aep346 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Use and effectiveness of dapagliflozin in type 1 diabetes: Clinical experience data of six months

José Ignacio Martínez Montoro , Andrea Fernández Valero , Fuentes Miguel Damas , José Luis Pinzón Martín , Tinahones Francisco J

IntroductionSodium-glucose cotransporter-2 inhibitors (SGLT2i) are a new class of oral antidiabetic drugs used for the treatment of type 2 diabetes mellitus. Recently, the SGLT2i dapagliflozin was approved for use in type 1 diabetes (T1DM) as an add-on to insulin therapy.Material and methodsWe conducted a retrospective observational study which included demographic and clinical-analytical data from 16 patient...

ea0070oc7.4 | Endocrine-related Cancer | ECE2020

Increased E2F1 mRNA and miR-17-5p expression may predict aggressiveness of pituitary neuroendocrine tumours

García-Martínez Araceli , Martínez-López Sebastián , López-Muñoz Beatriz , Cámara Rosa , Fajardo Carmen , Lamas Cristina , Silva-Ortega Sandra , Aranda Ignacio , Picó Antonio

Introduction: E2F1 regulates the expression of genes required for cell cycle progression and apoptosis. miR-17-5p regulates expression of E2F1. Both miR-17-5p and E2F1 have been described deregulated in cancer but they have been scarcely studied in human pituitary neuroendocrine tumours (PitNETs).The aim of the present study was to find biomarkers of aggressiveness in PitNETs and report the correlation between E2F1 and...

ea0070aep927 | Thyroid | ECE2020

Association between multifocality and one-year post-surgery response to treatment in papillary thyroid cancer

Monzón Mendiolea Andoni , Paja Fano Miguel , Leyre Martínez Martínez Adela , Merlo Pascual Ignacio , Araceli Calles Romero Laura , Covadonga Iglesias Hernández Natalia , Oleaga Alday Amelia

Introduction: American Thyroid Association (ATA) guidelines suggest considering hemithyroidectomy in patients with unifocal well-differentiated thyroid tumours,smaller than 4 cm, withoutpreoperative evidence of extrathyroidal extension (ETE) nor lymph node metastases. Although multifocal microcarcinomas are considered to increase the risk of structural disease recurrence from 1%–2% to 4%–6% compared to unifocal microcarcinomas, the ATA guidelines do not sugges...

ea0070aep928 | Thyroid | ECE2020

Usefulness of tissular heterogeneity analysis measured by elastography in the characterization of tyroid nodules

Sevillano Jiménez Maria , Ravé García Reyes , Socorro García García Clara , Torres Cuadro Alberto , Asunción Martínez Brocca María , Martín Hernández Tomas

Objectives: To assess whether the degree of heterogeneity of thyroid nodules defined by their elastographic characteristics is related to the cytological diagnosis and ultrasound classification of risk of malignancy.Material and Methods: Observational, prospective study. 101 thyroid nodules were analysed by quantitative elastographic analysis (shear-wave), measuring the stiffness of the lesion by global elastography and its standard deviation (s.d.</...

ea0070ep92 | Bone and Calcium | ECE2020

Bone mineral density in patients with human immunodeficiency virus infection. Assessment of vitamin D status, treatment and other associated risk factors

Puerma Ruiz Joaquin , Martín González Alba , Napky Jose , Gutiérrez Oliet Mercedes , Villa López Gema , Rubio García Rafael , Pulido Federico , Lora David , Alló Gonzalo , Martínez Diaz-Guerra Guillermo

Introduction: In patients with human immunodeficiency virus (HIV) infection, the prevalence of osteoporosis is higher in comparison with the general population. Anti-retroviral therapy (ART) use seems to be a possible risk factor there is also high prevalence of vitamin D deficiency among people living with HIV.Objectives: To describe bone mineral density (BMD) status in HIV-infected patients as well as its associated risk factors such as vit D levels.</...

ea0014s5.4 | Novel bioactive peptides – lessons from animals | ECE2007

Somatostatin, cortistatin and their new and old receptors: from comparative to translational endocrinology

Castaño Justo P. , Durán-Prado Mario , Vázquez-Martínez Rafael , Martínez-Fuentes Antonio J. , Gahete Manuel D. , Luque Raul M. , Malagón Maria M.

omatostatin, originally isolated from ovine hypothalami in 1973, and cortistatin, identified a decade ago in amphibians and then in human and rodents, are two highly related peptides thought to derive from a common ancestor gene. Owing to their high structural homology, both peptides bind with similar affinity to the five so-called somatostatin receptors (sst1-sst5), and exert virtually undistinguishable effects on several physiological targets, including inhibition of endocri...

ea0014s19.4 | Pituitary cell biology | ECE2007

Adipocytokines and pituitary function

Malagon Maria M. , Rodríguez-Pacheco Francisca , Martínez-Fuentes Antonio J. , Vázquez-Martínez Rafael , Tena-Sempere Manuel , Diéguez Carlos , P. Castaño Justo

It is widely accepted that, in addition to serving as a repository for energy reserves, adipose tissue is an active endocrine organ that secretes a variety of signalling molecules, the adipokines, which play important roles in the regulation of metabolism, energy balance, feeding behaviour, vascular homeostasis and immunity. In particular, leptin, resistin and adiponectin have been implicated in energy and glucose homeostasis. Additional neuroendocrine functions have also been...

ea0073aep775 | Thyroid | ECE2021

Behind seeming sepsis. An outstanding clinical debut of medullary thyroid carcinoma

Andoni Monzón Mendiolea , Paja Fano Miguel , Lizarraga Zufiaurre Aitzol , Oleaga Alday Amelia , Adela Leyre Martínez Martínez , Merlo Pascual Ignacio , Miren Josune Rodríguez Soto , Izquierdo Coca Jon

Procalcitonin (PCT) is a sepsis diagnostic marker and mortality predictor, although its elevation can be related to other diseases such as medullary thyroid carcinoma (MTC). A 72-year-old woman was transferred to the intensive care unit of our institution from another center. One week before, she had been admitted with a clinical picture of progressive malaise, fever, and dyspnea. Weeks before her admission, she had consulted for dyspnea, anorexia, asthenia, and weight loss. I...

ea0073aep828 | Late Breaking | ECE2021

Duodenal neuroendocrine tumor (siNET) and Rothmund-Thomson syndrome: a new association of a rare genetic disorder

Paja Fano Miguel , Adela L. Martínez-Martínez , Andoni Monzón , Josune Rodríguez-Soto , Merlo Ignacio , María J García-Barcina , Merino Sonia , M. Carmen González-Serrano

Rothmund-Thomson syndrome (RTS) usually presents with physical stigmata (poikiloderma, ectodermal dysplasia, juvenile cataracts…) and it´s associated with malignancies in patients with homozygous or compound heterozygous mutations in the RECQL4 helicase gene (RTS-II). Neoplasms include osteosarcoma in childhood and skin cancer later in life, with occasional malignancies affecting other tissues (leukemia, lymphoma and gastrointestinal adenocarcinomas). To ou...