ea0041oc9.1 | Endocrine Tumours | ECE2016
Hanin Omeiri
, Marthe Weinandts
, Lucile Lefevre
, Ludivine Drougat
, Guillaume Assie
, Rabin Marthe Rizk
, Jerome Bertherat
, Bruno Ragazzon
Introduction: Adrenocortical Carcinoma (ACC) is a rare and aggressive tumor with poor prognosis. Up to now, CTNNB1 (βcatenin) and TP53 mutations were the most frequent alterations identified in ACC. By a combination of genomic approaches, we have recently analyzed a cohort of 122 ACC (European Network for the Study of Adrenal Tumors, ENSAT). This work confirmed recurrent alterations in CTNNB1 and TP53 and revealed new genes not previous...