Searchable abstracts of presentations at key conferences in endocrinology

ea0014me10 | (1) | ECE2007

Indications, management and follow up of bariatric surgery

Fried Martin , Burguera Barto

European and world-wide obesity epidemic and continuously rising prevalence of obesity necessitates long-term efficient, economically bearable and patient safe solution. Bariatric surgery (surgery for obesity – different from lifestyle, body shaping surgery), is the most effective, low risk treatment modality for morbidly obese patients in terms of total weight loss and and long-term weight maintenance, currently available.It has to be stressed howe...

ea0038p199 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Evidence for improved mitochondrial efficiency in adipose tissue of T2DM women after malabsorptive but not restrictive bariatric surgery

Martinez de la Escalera Lucia , Jackisch Laura , Kyrou Ioannis , Vrbikova Jana , Hainer Vojtech , Fried Martin , Sramkova Petra , Piya Milan , Kumar Sudhesh , Tripathi Gyanendra , McTernan Philip

Aims/hypothesis: Genetic and functional defects in mitochondria are linked with phenotypes of obesity, hypercholesterolemia, and type 2 diabetes (T2DM). However, the impact on mitochondria during surgery-induced metabolic recovery is unknown. We therefore studied the effect of restrictive versus malabsorptive bariatric procedures on indicators of mitochondrial efficiency and control of biogenesis/function.Methods: Forty-three morbidly obese, T2DM consent...

ea0034p238 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2014

Systemic triglycerides as a key determinant of TLR regulated inflammatory risk in human adipose tissue post bariatric surgical intervention and weight loss

Kumsaiyai Warunee , Al-Daghri Nasser , Kyrou Ioannis , Vrbikova Jana , Hainer Vojtech , Fried Martin , Sramkova Petra , Barber Thomas , Kumar Sudhesh , Tripathi Gyanendra , McTernan Philip

Background and aims: Bariatric surgery can lead to a quick reversal in type 2 diabetes mellitus (T2DM) status. However, despite this reversal inflammatory responses may still persist via activation of Toll-like receptors (TLR) within adipose tissue (AT); with triglycerides (TGs) noted as a potential mediator of such inflammation. Therefore the aims of these studies were to understand the impact of TG changes, pre- and post-bariatric surgery, on TLR expression in ex vivo</e...

ea0034p269 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2014

Unfolded protein response in adipose tissue of obese diabetic women significantly improved 6 months post bariatric surgery, irrespective of malabsorptive or bypass operation type and correlates with plasma glucose concentration

Voyias Philip , Antonysunil Adaikala , Kumasaiyai Warunee , Kyrou Ioannis , Vrbikova Jana , Hainer Vojtech , Fried Martin , Sramkova Petra , Saravanan Ponnusamy , Kumar Sudhesh , McTernan Philip , Tripathi Gyanendra

Background: In obesity, excess nutrients and an increased demand for protein synthesis contribute to unfolded proteins accumulating within the endoplasmic reticulum and consequent activation of unfolded protein response (UPR). UPR in adipose tissue (AT) is critical to the initiation and integration of inflammation and insulin signalling pathways in obese and type 2 diabetes mellitus (T2DM) patients. The aim of this study was to examine whether novel malabsorptive or bypass bar...