Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep565 | Obesity and cardiovascular endocrinology | ECE2015

Patients with acute coronary syndrome have lower testosterone then healthy controls

Bednarova Adriana , Kuzma Martin , Payer Juraj

Objective: Several studies report the association of low testosterone with ischaemic heart disease although the results are inconsistent. In our study we tried to evaluate the relationship between sex hormones and incidence of acute coronary syndrome (ACS).Methods: This was a cross-sectional study. In 111 subjects (69 patients with ACS and 42 age-matched controls) we measured total testosterone, estradiol, SHBG, FSH, and LH by electrochemiluminiscence an...

ea0041ep1080 | Thyroid (non-cancer) | ECE2016

Thyroid screening in pregnancy –preliminary data from our outpatient clinic

Palenikova Patricia , Kollerova Jana , Bednarova Adriana , Kuzma Martin , Payer Juraj

Introduction: The adverse impact of overt hypothyroidism that complicates pregnancy outcomes is well-established. In order to eliminate these complications has long been discussion about the need for early detection of the disease of the thyroid gland in the population of women planning pregnancy, respectively in early pregnancy. In Slovakia, this effort resulted in the approval of screening for thyroid diseases in pregnancy and has been enshrined in a legislative in 2009. Obl...

ea0037gp.10.02 | Calcium, Vitamin D and Bone | ECE2015

Comparison of two methods in assessment of fracture risk of postmenopausal women with osteopenia

Kuzma Martin , Nemethova Eva , Killinger Zdenko , Payer Juraj

Introduction: More than half of osteopenic patients suffer from fracture (Fx), but BMD osteopenia is usually not considered for treatment initiation. FRAX, tool that can identify patients with high Fx risk based on major risk factors, can be used as an interventional threshold. Past few years, trabecular bone score (TBS), the bone quality determinant, is a promising method identifying the high-risk patients according to degradation of trabecular bone.Obj...

ea0035p677 | Growth hormone IGF axis basic | ECE2014

Positive impact of GH treatment on trabecular bone using grey-level texture analysis

Kuzma Martin , Kuzmova Zuzana , Vanuga Peter , Killinger Zdenko , Payer Juraj

Introduction: GH deficiency (GHD) is associated with reduced bone mineral density (BMD) and treatment leads to its increase. BMD, a quantitative bone parameter, doesnÂ’t bring whole information about bone status. Nowadays, bone quality shows as main determinant of bone strength, fracture prediction and treatment effect monitoring. A method to assess bone quality through the grey-level texture analysis from lumbar spine DXA scan is trabecular bone score (TBS).<p class="...

ea0041gp37 | Bone &amp; Calcium Homeostasis | ECE2016

Trabecular bone score in patients with inflammatory bowel diseases

Krajcovicova Anna , Kuzma Martin , Kaniaris Aristodimos Grigorios , Killinger Zdenko , Hlavaty Tibor , Payer Juraj

Introduction: Osteoporosis is known chronic complication of inflammatory bowel diseases (IBD). It is known that areal bone mineral density (aBMD) does not sufficiently reflect bone strength and quality. The trabecular bone score (TBS) provides an indirect measurement of bone microarchitecture, independent of aBMD.Aims and methods: The aim was to assess TBS in IBD patients with regard to disease behavior using in comparison with lumbar spine (LS) BMD. The...

ea0035p676 | Growth hormone IGF axis basic | ECE2014

GH replacement therapy affects the morphology and function of the left ventricle in patients with adult-onset GH deficiency

Dlesk Anton , Kamensky Gabriel , Lazurova Ivica , Kuzma Martin , Jackuliak Peter , Payer Juraj

Background: GH plays an important role in maintaining physiological morphology and function of the left ventricle (LV). In GH deficient (GHD) patients a systolic and/or diastolic LV dysfunction has been documented. LV systolic dysfunction results from reduced LV mass (LVM), which subsequently leads to a decrease of the LV ejection fraction (EF). Results from clinical trials evaluating the effect of GH replacement therapy on the morphological and functional changes of the LV in...

ea0056p175 | Bone ' Osteoporosis | ECE2018

Acromegaly patients with vertebral fractures, have lower trabecular bone score despite no difference in bone mineral density, than non-fractured patients and healthy controls

Kuzma Martin , Vanuga Peter , Sagova Ivana , Pavai Dusan , Jackuliak Peter , Killinger Zdenko , Binkley Neil , Genant Harry , Payer Juraj

Introduction: Patients with acromegaly, despite normal or even high bone mineral density (BMD), have prevalent vertebral fractures (VFs). HR-pQCT studies in acromegaly have proposed that impaired trabecular bone microarchitecture possibly plays a role in fragility fracture development. As such, we hypothesized that trabecular bone score (TBS) would be low in patients with acromegaly.Aim of the study: To compare BMD and TBS in acromegaly patients with and...