Searchable abstracts of presentations at key conferences in endocrinology

ea0032p989 | Thyroid (non-cancer) | ECE2013

Influence of smoking on hyperthyroidism severity in newly diagnosed Graves' disease patients

Martin Sorina , Florea Suzana , Fica Simona

Introduction: Smoking is an independent risk factor for Graves’ disease (GD) and an independent predictor for Graves’ophtalmopathy (GO), but the influence on hyperthyroidism severity was not established.Aim: To evaluate the relationship between smoking and thyroid function at diagnosis and after administration of antithyroid drugs (ATDs) in GD patients.Materials and methods: We prospectively investigated 116 newly diagnos...

ea0063p723 | Pituitary and Neuroendocrinology 2 | ECE2019

Elevated Chromogranin A levels in a patient with acromegaly – who is the culprit?

Mitrache Marius-Lucian , Leca Bianca , Martin Sorina , Fica Simona

Background: Chromogranin A (CgA) belongs to the family of granins, proteins which are an integral part of the secretory granules of neuroendocrine cells in endocrine glands and the diffuse neuroendocrine system. While it has become standard clinical practice to measure serum CgA in neuroendocrine tumors, various other non-endocrine conditions may increase this marker’s concentration and lead to diagnostic problems.Case report: We present the case of...

ea0041ep268 | Clinical case reports - Pituitary/Adrenal | ECE2016

Delayed diagnosis of isolated postpartum TSH deficiency: Sheehan’s syndrome or lymphocytic hypophysitis?

Iuliana Pascu , Minodora Betivoiu , Alexandra Nila , Sorina Martin , Simona Fica

Introduction: Sheehan’s syndrome (SS) is a rare complication of postpartum hemorrhage resulting in varying degrees of pituitary insufficiency. The diagnosis of SS has often been overlooked and thus delayed for many years due to its nonspecific signs and symptoms. Lymphocytic hypophysitis (LL) is also an uncommon autoimmune disorder that has to be suspected in women with recent delivery presenting with changes of one or more pituitary hormone secretions, especially when as...

ea0041ep292 | Clinical case reports - Pituitary/Adrenal | ECE2016

Congenital adrenal hyperplasia and multiple sclerosis: coincidence or not?

Betivoiu Minodora , Martin Sorina , Nila Alexandra , Pascu Iuliana , Fica Simona

Introduction: Congenital adrenal hyperplasia (CAH) is an inherited recessive disorder of adrenal steroidogenesis, generally caused by total or partial deficiency in 21-hydroxylase, due to deletions or mutations of CYP21 gene. Some studies suggest that the association between CAH and multiple sclerosis (MS) could be nonincidental: a possible MS susceptibility locus is on chromosome 6p21, on which the CYP21 gene is located.We report the c...

ea0041ep389 | Clinical case reports - Thyroid/Others | ECE2016

Graves’ orbitopathy- When the going gets tough… the tough get going?

Nila Alexandra , Betivoiu Minodora , Serbanescu Cristina , Martin Sorina , Fica Simona

Introduction: Thyroid disorders are common within the elderly population and are particularly challenging to diagnose and treat due to the presence of a wide variety of comorbidities. Graves’ ophtalmopathy remains a therapeutic predicament despite all progress made in understanding its pathogenesis, especially in the elderly population with severe presentation.Case presentation: We present the case of a 71-years-old female patient who was admitted i...

ea0041ep1015 | Thyroid (non-cancer) | ECE2016

Cardiovascular risk assessment using serum hs-CRP and Framingham risk score in newly diagnosed Graves’ disease patients

Martin Sorina , Betivoiu Minodora , Florea Suzana , Fica Simona

Introduction: In hyperthyroid patients mortality is increased by 20%, the major causes of death being cardiovascular disorders. Recent data suggest that subclinical or treated thyroid disease is associated with increased long-term vascular risk despite restoration of euthyroidism.Methods: We measured high-sensitivity C reactive protein (hs-CRP) in 116 newly diagnosed Graves’ disease (GD) patients, without prior antithyroid treatment. Levels of hs-CR...

ea0037ep652 | Pituitary: basic and neuroendocrinology | ECE2015

IGF1 deficiency in newly diagnosed Graves' disease patients

Martin Sorina , Betivoiu Minodora , Florea Suzana , Fica Simona

Introduction: Thyroid hormones influence GH/IGF1 axis, but previous studies reported discrepant results regarding serum IGF1 levels in hyperthyroidism. We have therefore investigated, at diagnosis, the relationship between serum IGF1 levels/IGF1 z scores and clinical and biological characteristics of Graves’ disease (GD) patients. We also compared IGF1 levels/IGF1 z scores, at diagnosis, between GD and autonomous hyperthyroidism patients.<p class="ab...

ea0037ep1252 | Clinical Cases–Thyroid/Other | ECE2015

Euthyroid Graves' ophthalmopathy in a patient with long-term amiodarone treatment

Betivoiu Minodora , Martin Sorina , Nila Alexandra , Fica Simona

Introduction: Ophthalmopathy, the most common extrathyroidal manifestation of Graves’ disease, occurs in 5% of cases in the absence of hyperthyroidism. Amiodarone, an iodine-rich antiarrhythmic drug, influences thyroid function, causing thyrotoxicosis or hypothyroidism, but its effect on thyroid autoimmunity is still a matter of debate.Case report: We report the case of a 58-year-old woman, suffering from non-sustained ventricular tachycardia, treat...

ea0035p3 | Adrenal cortex | ECE2014

Cardiovascular risk in Cushing's syndrome vs obesity

Martin Sorina , Ionita Andreea , Sirbu Anca , Florea Suzana , Fica Simona

Introduction: Cushing’s syndrome (CS) is associated with central obesity, hypertension, insulin resistance, dyslipidemia, prothrombotic state, manifestations which form a metabolic syndrome. Accelerated vascular senescence, due to metabolic and vascular changes, increases, in CS, the cardiovascular risk and the mortality rates compared to age- and gender-matched population. On the other hand, obesity itself is associated with numerous comorbidities, including hypertension...

ea0070aep982 | Thyroid | ECE2020

Exophtalmos in a hyperthyroid patient – it’s not always Graves ophthalmopathy

Martin Sorina , Mustata Theodor , Predescu Andrada , Fica Simona

Background: Hyperthyroidismcan be associated withorbitopathy that manifests as exophtalmos due to orbital tissue inflammation. Usually the diagnosis is straight forward when an autoimmune thyroid disorder is present, but conditions mimicking Graves orbitopathy can pose a diagnostic challenge.Case report: We report the case of a 51 year old caucasian woman who was referred to our clinic with asymmetrical exophtalmos in november 2019. The patient stated th...