ea0086p89 | Neuroendocrinology and Pituitary | SFEBES2022
MacFarlane James
, Clark Graeme
, Rodger Fay
, Martin Ezequiel
, Allinson Kieren
, Gurnell Mark
, Casey Ruth
Background: Sporadic non-functioning pituitary adenomas (NFPAs) are described as having quiet mutational landscapes. Genes with recurrent somatic alterations have not been identified by previous studies examining heterogeneous pituitary tumour populations. Existing biomarkers have limited ability to discriminate NFPAs with a predisposition for regrowth from those that will follow a more indolent course after primary surgery. We undertook somatic sequencing, in an enriched coho...