Searchable abstracts of presentations at key conferences in endocrinology

ea0035oc10.2 | Endocrine Tumours | ECE2014

The cytotoxic effect of sunitinib on human bronchial carcinoid cell lines and primary cultures is counteracted by EGF and IGF-1 but not by VEGF

Gagliano Teresa , Gennari Giulia , Tassinari Martina , Bellio Mariaenrica , Gentilin Erica , Benfini Katiuscia , Uberti Ettoredegli , Zatelli Maria Chiara

Background: Bronchial carcinoids (BC) are rare tumors originating from endocrine cells dispersed in the respiratory epithelium. The main BC treatment is surgery, which is not feasible for large, infiltrating and metastatic disease. In these settings, medical therapy is often tried. Therefore it is important to identify new therapeutic targets and new molecules capable of providing adequate medical treatment for patients with BC. Sunitinib, is an oral, small-molecule, multi-tar...

ea0035p11 | Adrenal cortex | ECE2014

VEGF autocrine secretion is enhanced by EGFR activation trough ERK1/2 phosphorylation in human adrenocortical carcinoma cell lines

Gagliano Teresa , Di Pasquale Carmelina , Gentilin Erica , Mole Daniela , Tassinari Martina , Bellio Mariaenrica , degli Uberti Ettore , Zatelli Maria Chiara

Adrenocortical cancer (ACC) is still orphan of medical treatment. Our preliminary data show that EGF induces ACC cell lines proliferation (+20 and +10% vs control in SW13 and NCI-H295 cell lines respectively). EGF receptor (EGFR) expression is higher and ubiquitous in SW13 cells, while it is weaker in NCI-H295 cells, where it is present only on the membrane. Aim of our study is to analyze EGFR downstream signalling in ACC cell lines.EGF induces VEGF synt...