Searchable abstracts of presentations at key conferences in endocrinology

ea0022p257 | Developmental endocrinology | ECE2010

Mineralocorticoid pathway in newborns: evidence for a physiological renal aldosterone unresponsiveness

Martinerie Laetitia , Viengchareun Say , Boileau Pascal , Lombes Marc

Aldosterone is the main steroid hormone controlling sodium homeostasis in human. During the neonatal period, full term newborns and more specifically premature infants, are subjected to an impaired renal capacity to reabsorb sodium, responsible for sodium loss and failure to thrive which could be linked to a renal aldosterone unresponsiveness at birth. A clinical prospective study on 50 newborns and their mothers, revealed high aldosterone and renin levels in umbilical blood s...

ea0063oc12.2 | Endocrine Connections 2 | ECE2019

Epigenetic programming of transgenerational hypertension in preterm birth mice

Dumeige Laurence , Nehlich Melanie , Viengchareun Say , Pussard Eric , Lombes Marc , Martinerie Laetitia

Renal and cardio-vascular complications of prematurity are well established, notably those associated with renal tubular immaturity, responsible for major salt loss at birth, as well as early hypertension in adulthood. However, the molecular underlying mechanisms remain poorly understood. Our objective was to investigate the impact of preterm birth on the ontogenesis of renal corticosteroid pathways, to evaluate its implication on perinatal complications and on the emergence o...

ea0063p1018 | Interdisciplinary Endocrinology 2 | ECE2019

MicroRNAs regulate aldosterone signaling by post-transcriptional control of mineralocorticoid receptor expression

Vu Thi-An , Lema Ingrid , Bouligand Jerome , Martinerie Laetitia , Lombes Marc , Viengchareun Say

The Mineralocorticoid Receptor (MR), a hormone-activated transcription factor that mediates sodium-retaining action of aldosterone, is highly expressed in the distal nephron in which large variations in extracellular fluid tonicity are generated by the cortico-papillary gradient. However, mechanisms regulating MR expression remain sparse. We recently showed that extracellular tonicity modulates renal MR expression through posttranscriptional mechanisms (Viengchareun, Mol Endoc...

ea0049oc5.5 | Cardiovascular Endocrinology | ECE2017

Sex dimorphism of renal corticosteroid signaling during development and long term consequence on blood pressure

Dumeige Laurence , Storey Caroline , Decourtye Lyvianne , Nehlich Melanie , Lhadj Christophe , Viengchareun Say , Kappeler Laurent , Lombes Marc , Martinerie Laetitia

Sex differences have been demonstrated in various biological processes such as arterial blood pressure. However, the potential sex dimorphism of the renin-angiotensin-aldosterone system and, by extension, the mineralocorticoid receptor (MR) signaling pathway, major regulators of blood pressure, has only been poorly studied, notably in the kidney. Basal systolic blood pressure (SBP) and heart rate (HR) were measured in adult male and female mice. Renal gene expression studies o...

ea0063oc7.2 | Endocrine Connections 1 | ECE2019

Thyroid hormones are new key regulators of glucocorticoid metabolism

Bessiene Laura , Hescot Segolene , Bourdin-Pintueles Alexandra , Dumeige Laurence , Vitellius Geraldine , Perrot Julie , Xu Qiong-Yao , Vu Thi-An , Sachs Laurent , Pussard Eric , Lombes Marc , Viengchareun Say , Martinerie Laetitia

The 11-beta hydroxysteroid dehydrogenase (11βHSD) isozymes are well-known regulators of glucocorticoid hormone metabolism: 11βHSD2, mostly expressed in the distal nephron, converts cortisol [F] into cortisone [E] in humans or corticosterone into 11-dehydrocorticosterone in rodents (11-dehydro derivatives being inactive compounds), and 11βHSD1, ubiquitously expressed but predominantly in the liver, catalyzes the opposite reaction. Under pathophysiological conditi...