Endocrine Abstracts

JAK2/STAT5 is the principal growth hormone (GH) signaling pathway related to body growth. It is positively regulated by glucocorticoid receptor (GR) and hepatocyte nuclear factor 1 (HNF-1) and downregulated by activation of tyrosine-phosphatases SHP-1,-2 and PTP-1B, and by GH-induction of suppressors of cytokine signaling (CIS/SOCS) that block GHR or JAK2, and promote internalization/degradation of signaling complexes. This pathway is desensitized in liver of adult transgenic ...

GH and IGF1 play an important role in cardiac development and function. Conditions leading to abnormal GH levels are associated with cardiovascular disease. Although acromegaly is associated with hypertension, insulin resistance, diabetes type 2 and dislipemia, several studies ascribe the heart alterations displayed by these patients to the direct action of chronically elevated GH and IGF1 levels.Given that insulin acts as a growth factor to the heart an...