Searchable abstracts of presentations at key conferences in endocrinology

ea0049gp35 | Bone & Calcium Homeostasis 1 | ECE2017

Aldosterone and parathyroid hormone – is there a connection?

Ventura Mara , Melo Miguel , Oliveira Diana , Martins Diana , Lages Adriana , Cunha Nelson , Carrilho Francisco

Introduction: Recent studies seem to support a bidirectional positive interaction between aldosterone and parathyroid hormone (PTH). Understanding the normal physiological relationship between renin-angiotensin-aldosterone system (RAAS) and PTH is of clinical interest because their inappropriate activity may negatively impact cardiovascular and skeletal health.Objective: To evaluate the presence of an interaction between aldosterone and PTH in a cohort o...

ea0037ep512 | Diabetes (complications & therapy) | ECE2015

Continuous subcutaneous insulin infusion decreases hypoglycaemia during nighttime

Vicente Nuno , Cardoso Luis , Baptista Carla , Barros Luisa , Guelho Daniela , Oliveira Diana , Martins Diana , Carrilho Francisco

Introduction: Continuous subcutaneous insulin infusion (CSII) and multiple daily injections (MDI) are forms of intensified insulin therapy and the most used regimens for type 1 diabetes (T1D). Owing to its continuous basal output, hypoglycaemic events tend to be rarer with CSII. Our goal was to evaluate the differences in nocturnal hypoglycemia between these two treatment strategies.Methods: Retrospective analysis of 61 patients who had performed continu...

ea0049ep203 | Neuroendocrinology | ECE2017

Quality of life in patients with neuroendocrine tumors treated with 177Lu-[DOTA0,Tyr3]-octreotate: a Single Tertiary Care Portuguese Center Experience

Lages Adriana , Moreira Helder , Costa Gracinda , Oliveira Patricia , Oliveira Diana , Martins Diana , Ventura Mara , Cunha Nelson , Carrilho Francisco

Introduction and purpose: 177Lu-[DOTA0,Tyr3]octreotate (177Lu-DOTA-TATE) is a radiopharmaceutical frequently used in peptide receptor radionuclide therapy (PRRT), which is a promising treatment modality in patients with metastasized neuroendocrine tumors (NETs). We purpose to evaluate the quality of life (QoL) in patients with somatostatin receptor positive inoperable or metastatic NETs throughout the three cycle’s (with three months intervals) proto...

ea0049ep1009 | Pituitary - Clinical | ECE2017

Aggressive pituitary tumors: a tertiary center experience

Lages Adriana , Paiva Isabel , Gomes Leonor , Oliveira Patricia , Belo Francisco , Oliveira Diana , Martins Diana , Ventura Mara , Cunha Nelson , Carrilho Francisco

Background: Pituitary adenomas (PA) are common intracranial tumors that are mainly considered benign. A small group of patients exhibit clinically aggressive behavior sometimes unrelated to the histopathological or radiological features.Methods: Twelve patients were selected harboring a PA with clinical features of aggressiveness. All the patients underwent pre and postoperative endocrinologic/neuroradiologic evaluation.Results: 10...

ea0041ep115 | Bone & Osteoporosis | ECE2016

The effect of anorexia nervosa on bone

Vicente Nuno , Rodrigues Dircea , Barros Luisa , Guelho Daniela , Cardoso Luis , Oliveira Diana , Martins Diana , Ventura Mara , Lages Adriana , Carrilho Francisco

Introduction: One of the most common endocrine complications of anorexia nervosa (AN) is the decrease in bone mineral density. The authors evaluated the predictive factors of osteopenia and osteoporosis in AN patients admitted with low weight.Patients and methods: Retrospective analysis of 45 patients admitted with AN between 2001 and 2015 in the Endocrinology department, corresponding to 63 admissions. Bone mineral density was classified according to WH...

ea0056gp68 | Cardiovascular | ECE2018

Turner syndrome and cardiovascular risk

Marques Bernardo , Bastos Margarida , Oliveira Diana , Martins Diana , Lages Adriana , Ventura Mara , Cunha Nelson , Fadiga Lucia , Catarino Diana , Carrilho Francisco

Introduction: Turner Syndrome (TS) is associated with cardiovascular anomalies and account for a threefold higher mortality in these women. The most common findings are congenital malformations of the heart (CMH), aortic dissection, valvular heart disease (VHD), hypertension and ischemic heart disease. It has been suggested that the ocurrence of cardiovascular disease in TS women is related to their karyotype and possibly to growth hormone (GH) treatment. Our study aimed to as...

ea0056p104 | Clinical case reports - Pituitary/Adrenal | ECE2018

A new gene – TMEM127 – in familial pheochromocytoma/paraganglioma syndromes

Ventura Mara , Paiva Isabel , Melo Miguel , Lages Adriana , Oliveira Diana , Martins Diana , Cunha Nelson , Fadiga Lucia , Catarino Diana , Carrilho Francisco

Introduction: Pheochromocytomas are catecholamine-producing tumors originated from the chromaffin cells of the adrenal medulla. Although usually sporadic, this tumors could be associated with germline mutations in about 40% of cases. TMEM127 has recently been identified as a novel gene conferring increased susceptibility to pheochromocytoma.Case report: A 42-year-old woman was referred to our Hospital to perform a right adrenalectomy for pheochromocytoma...

ea0056ep68 | Diabetes, Obesity and Metabolism | ECE2018

Diabetic ketoacidosis and dapagliflozin: a case report

Catarino Diana , Ribeiro Cristina , Oliveira Diana , Martins Diana , Lages Adriana , Ventura Mara , Cunha Nelson , Fadiga Lucia , Marques Bernardo , Carrilho Francisco

Introduction: Dapagliflozin is an oral antidiabetic drug, recently approved for type 2 diabetes and is a sodium-glucose cotransporter type 2 inhibitor (iSGLT2). Its mechanism of action is glycosuria induction, associated with lowering glycemia. The effects of SGLT2 inhibition are insulin-independent, and efficacy is not affected by declining β-cell function or insulin resistance. Additional benefits: weight loss, reduction in blood pressure, lower inciden...

ea0049ep44 | Adrenal cortex (to include Cushing's) | ECE2017

Late-night salivary cortisol: cut-off definition and diagnostic value in Cushing’s syndrome

Lages Adriana , Frade Joao , Paiva Isabel , Oliveira Patricia , Oliveira Diana , Martins Diana , Ventura Mara , Cunha Nelson , Rebelo-Marques Alexandre , Antunes Susana , Leitao Fatima , Carrilho Francisco

Background: The diagnosis of Cushing’s syndrome (CS) remains a challenge in clinical endocrinology. Several screening tests have been proposed to establish hypercortisolism. Late-night salivary cortisol (LNSC) is used as screening tool, however, individualized cut-off levels for each population must be defined.Methods: Three group of subjects were studied: healthy volunteers, suspected CS and proven CS. All patients collected saliva at 23.00 h using...

ea0049ep45 | Adrenal cortex (to include Cushing's) | ECE2017

Adrenal involvement in MEN1 families

Ventura Mara , Melo Miguel , Gomes Leonor , Saraiva Joana , Barros Luisa , Rodrigues Dircea , Oliveira Diana , Martins Diana , Lages Adriana , Cunha Nelson , Carrilho Francisco

Introduction: MEN1 is a rare autosomal dominant syndrome typically characterized by neoplastic lesions of parathyroid glands, anterior pituitary gland and endocrine pancreas. Several other tumours are associated with this syndrome, including adrenal lesions, but their prevalence and clinical characteristics (endocrine secretion and aggressiveness) are largely unknown.Objective: To determine the prevalence, clinical characteristics and the possible genoty...