Searchable abstracts of presentations at key conferences in endocrinology

ea0016p389 | Neuroendocrinology | ECE2008

Body fat excess and GH-stimulated levels in adult patients with Prader–Willi syndrome

Grugni Graziano , Crino Antonino , Bertocco Paride , Sartorio Alessandro , Marzullo Paolo

The GH response to standard provocative tests is significantly lower in adult patients with Prader–Willi syndrome (PWS) than obese controls with similar body mass index (BMI). Nevertheless, BMI is an inadequate measure of body composition in PWS, because PWS harbour a higher fat mass than simple obesity, under the same degree of weight excess. This study evaluated either the GH response to combined GHRH+arginine administration and the fat body mass, by dual energy X-ray a...

ea0070oc5.3 | Thyroid | ECE2020

Acute pancreatitis associated with methimazole treatment: A retrospective analysis of administrative health databases conducted in the Piedmont Region, Italy

Caputo Marina , Pecere Alessandro , Sarro Andrea , Zibetti Angelica , Marzullo Paolo , Aimaretti Gianluca , Barone-Adesi Francesco

Purpose: Methimazole (MMI) is a widely used antithyroid agent for first-line treatment of hyperthyroidism. A warning has been recently issued by the European Medicine Agency (EMA) regarding a potential increased risk of acute pancreatitis (AP) in MMI users, based on evidences from published case reports and post-marketing surveillance. The aim of this study was to investigate the association between MMI treatment and the diagnosis of AP in drug users.Mat...

ea0014oc3.7 | Endocrine tumors & neoplasia | ECE2007

Fasting insulin levels are predictors of colonic lesions in patients with acromegaly: an observational, open, prospective study in 189 patients

Colao Annamaria , Pivonello Rosario , Galdiero Mariano , Auriemma Renata S. , Ferone Diego , Marzullo Paolo , Lombardi Gaetano

Elevated insulin levels are correlated with colonic adenomas and carcinomas in the general population. Patients with acromegaly are considered at high risk to develop colonic lesions and have a high insulin levels. To evaluate the role of insulin levels on colonic polyps (hyperplastic, adenomatous, single or synchronous) or adenocarcinoma in acromegaly we designed this analytical, observational, open, prospective, study enrolling 189 patients (100 women, 89 men, age 20–82...

ea0073aep201 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Liraglutide for weight management in syndromic obesity: effects in overgrowth adult Beckwith–Wiedemann syndrome

Caputo Marina , Daffara Tommaso , Bellone Simonetta , Mancioppi Valentina , Marzullo Paolo , Aimaretti Gianluca , Prodam Flavia

ContextGenetic obesity, including syndromic and non-syndromic forms, represent a minority of cases but gene dysregulations make their management particularly difficult. Among them, Beckwith–Wiedemann syndrome (BWS) is a multisystem human genomic imprinting disorder characterized by overgrowth, macroglossia, abdominal wall defects, hemi hyperplasia, enlarged abdominal organs, and an increased risk of embryonal tumours. The syndrome is caused by genet...

ea0056p616 | Neuroendocrinology | ECE2018

Use of a new classification algorithm based on administrative health databases to estimate incidence and prevalence of acromegaly in Piedmont Region, Italy

Caputo Marina , Ucciero Andrealuna , Mele Chiara , De Marchi Lucrezia , Magnani Corrado , Marzullo Paolo , Barone-Adesi Francesco , Aimaretti Gianluca

Background and aim: Information on incidence and prevalence of acromegaly usually originates from studies performed in referral endocrine care centers, whose catchment areas do not generally cover the entire population. Administrative databases can provide key information to assess the impact of acromegaly on patients and health systems. Our study aimed at estimating the prevalence and incidence data of acromegaly stratified by age and sex using data obtained in the Piedmont r...

ea0081p82 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Irisin in pediatric patients with Prader Willi Syndrome: the role of body composition and glucose metabolism

Mai Stefania , Fintini Danilo , Mele Chiara , Convertino Alessio , Bocchini Sarah , Grugni Graziano , Aimaretti Gianluca , Vietti Roberta , Scacchi Massimo , Crino Antonino , Marzullo Paolo

Irisin is a myokine involved in the browning of white adipose tissue and in the regulation of energy expenditure, glucose tolerance and insulin sensitivity. It was previously demonstrated that obese adults with Prader-Willi syndrome (PWS) harbor lower irisin levels than individuals with common obesity. Significant associations seem to relate irisin to muscle mass, REE, insulin resistance and triglycerides and also the strongest independent predictors of irisin levels were PWS ...

ea0081ep90 | Adrenal and Cardiovascular Endocrinology | ECE2022

Tumor enlargement in adrenal incidentaloma is related to glaucoma and statin treatment: are there two new prognostic features?

Ferrero Alice , Daffara Tommaso , Mele Chiara , Zavattaro Marco , Romanisio Martina , Cavigiolo Beatrice , Costelli Samuele , Caputo Marina , Marzullo Paolo , Prodam Flavia , Aimaretti Gianluca

Aim: The uncertainty on the management of small adrenal incidentalomas (AIs) in guidelines still represents a challenge in real clinical practice. The aim of the study was to identify risk factors for morphological or functional changes during follow-up by using clinical, radiological, and pathological features.Methods: We retrospectively evaluated demographic (gender and age at diagnosis), clinical (weight, height, body mass index, smoking habit, comorb...