Endocrine Abstracts

Introduction: Tolvaptan, a selective vasopressin 2 receptor antagonist is proving beneficial in managing hyponatremia secondary to SIADH.Case report: A 75-year-old male with history of traumatic SAH developed hyponatremia secondary to SIADH. He had multiple admissions with symptomatic hyponatremia. His sodium level kept dropping despite putting on fluid restriction and trial of sodium chloride tablets. He was started on Tolvaptan 7.5 once weekly initiall...

Background: Nice guideline recommends using TSH receptor antibody as a tool for classification of hyperthyroid patients; and considering technetium scanning of the thyroid gland if TRAbs are negative. Early diagnosis of TED is also essential for treatment to be effective. The most common way to assess the severity of TED is to use the Clinical Activity Score (CAS) 7-point scale.Objectives: We aimed to evaluate if hyperthyroid patients are classified corr...

Case: This 23-year-old lady initially presented in 2013 with headaches, galactorrhoea and secondary amenorrhoea. Visual fields were normal to confrontation. Prolactin levels were elevated at 3028miu/l. MRI pituitary revealed a 14x13x15mm adenoma pushing the pituitary stalk posteriorly, and compressing the left side of the optic chiasm.Initial Management: Cabergoline was commenced (250mg twice weekly), with good clinical ...

Background: Calcification or ossification of the auricular cartilage, known as "petrified ears," is a rare condition typically linked to local trauma, frostbite, or inflammation. Endocrinopathies, especially adrenal insufficiency, has been historically linked with this condition. There are several reports of its association with different causes of primary adrenal insufficiency but only a very few reported cases of secondary adrenal insufficiency leading to bilateral a...

Pituitary apoplexy is an uncommon, but well recognised clinical syndrome, which usually results from ischaemic or haemorrhagic necrosis of pituitary gland, which is frequently precipitated by an existing pituitary adenoma. Early diagnosis of this condition is essential as prompt management may be life and vision saving. We are highlighting a case of Pituitary apoplexy on long term Cabergoline for Prolactinoma.Case report: A 62 year old l...

Introduction: Testosterone <5nmol/l is commonly seen in conditions such as PCOS however when testosterone is >5nmol/l, concerns start to rise about more sinister causes. Here, we present a case of a female who was referred to clinic with testosterone >5mmol/lCase: A 32 year old presented to the GP with a heavier than usual menstrual period. For an unknown reason, the GP checked testosterone, which came back a...

Background: Adrenal insufficiency (AI) requires life-long glucocorticoid substitution therapy (1), and bears significant risks of infection, cardiovascular (CV) & metabolic disease burden. Historically Hydrocortisone (HC) has been the mainstay of treatment. Prednisolone is a once-daily alternative due to a longer half-life (up to 3.2 hrs). Currently, there is no discernible evidence supporting the superiority of either medication (2).Objective: To ex...

Background: Primary adrenal insufficiency or Addison’s disease (AD) is characterized by glucocorticoid and mineralocorticoid deficiency due to lesion of the adrenal glands through different mechanisms (1). Addison’s disease is a risk factor for adverse maternal and neonatal outcomes. Close monitoring is required for these patients during the intrapartum and postpartum periods.(2)Objective: Retrospective evaluation of the management of Addison&#...

Background: DNA methylation analysis has been proven useful biomarker in patients with colon (1-3), breast (4), and lung cancer (5). However, the clinical utility of this method in neuroendocrine neoplasms (NENs) is limited. Our research group has previously worked on the role of circulating cell-free tumour DNA (ctDNA) in neuroendocrine tumours (NETs) and thyroid cancers. Preliminary findings showed that this is a potentially useful clinical tool (6). We are expanding our res...

Background: Omission of steroids and unsafe steroid prescription in Adrenal insufficiency (AI) patients during intercurrent illness or surgery is unfortunately common, and can lead to adrenal crisis and potentially death. Anna Mitchell et al, New Castle-upon-Tyne have demonstrated potential use of electronic automation with steroid alerts to minimise human error for ensuring patient safety.Objectives: 1. Similar use of artificial intelligence wa...